Jewim Pharma


Global Pharmatrade
Full Prescribing Info
Oxymetazoline hydrochloride.
Each mL contains: Oxymetazoline Hydrochloride 500 mcg.
Pharmacology: Oxymetazoline is a direct-acting sympathomimetic with marked alpha-adrenergic activity. It is a vasoconstrictor which reduces swelling and congestion when applied to mucous membranes. It acts within a few minutes and the effect lasts for up to 12 hours. It is used as the hydrochloride for the symptomatic relief of nasal congestion.
For the symptomatic relief of nasal congestion associated with acute or chronic rhinitis, common cold, sinusitis, hay fever and other allergies.
Dosage/Direction for Use
Two (2) or three (3) sprays in each nostril 2 times a day, in the morning and evening or as prescribed by the physician.
Directions for Use: Blow nose gently. With the head upright, spray the medicine into each nostril. Sniff briskly while squeezing the bottle quickly and firmly. For best results, spray twice or thrice into each nostril, wait 3 to 5 minutes to allow the medicine to work, and then blow the nose gently and thoroughly. Repeat until the complete dose is used.
Rinse the tip of the spray bottle with hot water, taking care not to suck water into the bottle, and dry with a clean tissue. Replace the cap right after use.
Do not use the container for more than one person to avoid spreading infection.
When taken in large doses, Oxymetazolline may cause hypotension, presumably because of a central clonidine-like effect.
Treatment: Treatment is symptomatic.
Contraindicated in patients where there is inflammation of mucosa of the nasal vestibule with incrustation (rhinitis sicca) and in patients with phaeochromocytoma, hyperthyroidism, glaucoma, hypertension and in patients with hypersensitivity to the drug or any of its components.
Rebound congestion may occur after frequent or prolonged use.
Special Precautions
Accidental administration by mouth may cause depression of the CNS with marked reduction of body temperature and bradycardia sweating, drowsiness, and coma. Should be used with caution in children and generally avoided in children under 2 years of age. Do not exceed the recommended dosage and do not use for more than 72 hours because of tolerance effect and possible residual congestion.
Adverse Reactions
After local use of oxymetazoline transient irritation may occur. Rebound congestion may occur after frequent or prolonged nasal use. Systemic effects, including nausea, headache and dizziness have occurred after local administration.
Drug Interactions
May cause hypotensive crisis if used during treatment with monoamine oxidase inhibitors (MOAIs).
Store at temperatures not exceeding 30°C.
ATC Classification
R01AA05 - oxymetazoline ; Belongs to the class of topical sympathomimetic agents used as nasal decongestants.
Nasal spray 0.05% w/v x 5 mL x 1's, 10 mL x 1's.
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