A. Menarini


Concise Prescribing Info
Nebivolol HCl
Treatment of essential HTN & stable mild & moderate chronic heart failure in addition to standard therapies in elderly patients.
Dosage/Direction for Use
HTN Adult 5 mg once daily. In combination w/ other antihypertensive agents 5 mg plus hydrochlorothiazide 12.5-25 mg. Elderly >65 yr Start at 2.5 mg daily. May be increased to 5 mg daily. Chronic heart failure Initially 1.25 mg once daily, increase at interval of 1-2 wk based on patient's tolerability to 2.5, 5 & 10 mg once daily.
May be taken with or without food: Preferably taken at the same time each day.
Hypersensitivity. Liver insufficiency or impairment. Acute heart failure, cardiogenic shock or episodes of heart failure decompensation. Sick sinus syndrome including SA block; 2nd- & 3rd-degree heart block (w/o a pacemaker); history of bronchospasm & bronchial asthma; untreated pheochromocytoma; metabolic acidosis; bradycardia (heart rate <60 bpm); hypotension (systolic BP <90 mmHg); severe peripheral circulatory disturbances.
Special Precautions
Concomitant use w/ anesth. Untreated CHF, ischemic heart disease. Peripheral circulatory disorders (Raynaud's disease or syndrome, intermittent claudication); 1st-degree heart block; Prinzmetal's angina. DM, hyperthyroidism, COPD, history of psoriasis. May increase sensitivity to allergens & severity of anaphylactic reactions. Avoid abrupt w/drawal. Severe renal impairment. Galactose intolerance, Lapp lactase deficiency or glucose-galactose malabsorption. May impair ability to drive or operate machinery. Pregnancy & lactation. Childn & adolescent. Elderly >75 yr.
Adverse Reactions
Headache, dizziness, paresthesia; dyspnea; constipation, nausea, diarrhea; tiredness, edema; bradycardia.
Drug Interactions
Class I antiarrhythmics & amiodarone, verapamil or diltiazem type Ca antagonist, centrally-acting antihypertensives, anesth, insulin & oral antidiabetic drugs. Digitalis glycosides; dihydropyridines; TCAs, barbiturates, phenothiazines, sympathicomimetic agents. CYP2D6 inhibitors, cimetidine, nicardipine.
MIMS Class
ATC Classification
C07AB12 - nebivolol ; Belongs to the class of selective beta-blocking agents. Used in the treatment of cardiovascular diseases.
Nebilet tab 5 mg
30's (P18.75/tab)
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