Hypersensitivity to nebivolol or to any of the excipients of Nebilet. Liver insufficiency or liver function impairment. Acute heart failure, cardiogenic shock or episodes of heart failure decompensation requiring IV inotropic therapy.
In addition, as with other β-blocking agents, Nebilet is contraindicated in sick sinus syndrome, including sino-atrial block; 2nd- and 3rd-degree heart block (without a pacemaker); history of bronchospasm and bronchial asthma; untreated pheochromocytoma; metabolic acidosis; bradycardia (heart rate <60 bpm prior to therapy); hypotension (systolic blood pressure <90 mmHg); severe peripheral circulatory disturbances.
Hepatic Insufficiency: Data in patients with hepatic insufficiency or impaired liver function are limited. Therefore the use of Nebilet in these patients is contraindicated.