Neocyte

Neocyte

filgrastim

Manufacturer:

UNILAB, Inc

Distributor:

UNILAB, Inc
Concise Prescribing Info
Contents
Filgrastim (recombinant human granulocyte colony stimulating factor [rhG-CSF])
Indications/Uses
Chemotherapy-induced neutropenia.
Dosage/Direction for Use
IV/IM Patient on low dose chemotherapy or w/ nonserious marrow depression damage 1.25 mcg/kg/day. Patient w/ high intensity chemotherapy or obvious decline of granulocytes 2.5 mcg/kg/day for 7 days. Patient w/ neutrophilic granulocytes <1x 109/L 5 mcg/kg/day.
Contraindications
Hypersensitivity to rhG-CSF, Escherichia coli-derived proteins. Increased dose of cytotoxic chemotherapy beyond established dosage regimens. Kostmann's syndrome w/ abnormal cytogenetics.
Special Precautions
Splenic rupture, severe sick cell crisis. Do not administer 24 hr before to 24 hr after cytotoxic chemotherapy. Chemotherapy & radiation therapy. Chronic myeloid leukemia & myelodysplasia. CV effects. Regularly monitor patients w/ preexisting cardiac conditions; hematocrit & platelet count; complete blood count 2 times a wk during therapy. Allergic reaction eg, rash, urticarial, facial edema, wheezing, dyspnea, hypotension & tachycardia. Cutaneous vasculitis, immunogenicity, acute resp distress syndrome. Increased doses of chemotherapy. Osteoporosis. Infections causing myelosuppression. Pregnancy & lactation. Childn <18 yr.
Adverse Reactions
Nausea, vomiting, abdominal pain, thrombocytopenia, anemia; increased γ-glutamyl transpeptidase, alkaline phosphatase, lactate dehydrogenase & uric acid; decreased glucose & hyperuricemia; bone pain, myalgia. Mucosal inflammation, constipation, diarrhea; hepatomegaly; headache, anorexia; chest pain, musculoskeletal pain, osteoporosis; cough, pharyngolaryngeal pain; alopecia, skin, rash; erythema, swelling or pruritus; fatigue, generalized weakness.
Drug Interactions
Lithium may potentiate the release of neutrophils.
ATC Classification
L03AA02 - filgrastim ; Belongs to the class of colony stimulating factors. Used as immunostimulants.
Presentation/Packing
Form
Neocyte inj 300 mcg/mL
Packing/Price
1's
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