Losartan Potassium: Adverse effects include dizziness and dose-related orthostatic hypotension. Hypotension may occur particularly in patients with volume depletion (eg, those who received high-dose diuretics). Losartan potassium may cause hyperkalemia in patients with renal disease. Other adverse effects that have been reported with angiotensin II receptor antagonist include respiratory tract disorder, back pain, gastrointestinal disturbances, fatigue and neutropenia.
Hydrochlorothiazide: Thiazide diuretics may cause a number of metabolic disturbances especially at high doses. It may provoke hyperglycemia and glycosuria in diabetic and other susceptible patients. It may cause hyperuricemia and precipitate attacks of gout in some patients. Administration of hydrochlorothiazide may be associated with electrolyte imbalances including hypochloremic alkalosis, hyponatremia and hypokalemia. Hypokalemia intensifies the effect of digitalis on cardiac muscle and administration of digitalis or its glycoside may be temporarily suspended. Patients with cirrhosis of the liver are particularly at risk from hypokalemia.