Neosartan Plus

Neosartan Plus Mechanism of Action

losartan + hydrochlorothiazide

Manufacturer:

GXI

Distributor:

Metro Drug
Full Prescribing Info
Action
Pharmacology: Pharmacodynamics: Losartan Potassium: It is an angiotensin II receptor blocker with antihypertensive activity due mainly to selective blockage of AT1 receptors and the consequent reduced pressure effect of angiotensin II.
Hydrochlorothiazide: It is a diuretic antihypertensive.
Pharmacokinetics: Losartan Potassium: It is readily absorbed from the gastrointestinal tract (GIT) following oral administration, with an oral bioavailability of about 33%. It undergoes first-pass metabolism to form an active carboxylic acid metabolite E-3174 (EXP-3174), which has greater pharmacological activity than losartan and some inactive metabolites. Metabolism is primarily by cytochrome P450 isoenzyme CYP2C9 and CYP3A4. Peak plasma concentrations of losartan and E-3174 occur about 1 hr and 3-4 hrs, respectively, after an oral dose. Both losartan and E-3174 are more than 98% bound to plasma proteins. Losartan is excreted in the urine and in the feces via bile, as unchanged drug and metabolites. Following oral dosing, about 35% of the dose is excreted in the urine and about 60% in the feces. The terminal elimination t½ of losartan and E-3174 are about 1.5-2.5 hrs and 3-9 hrs, respectively.
Hydrochlorothiazide: It is fairly rapidly absorbed from the GIT. It is reported to have a bioavailability of about 65-70%. It has been estimated to have a plasma t½ of between about 5-15 hrs and appears to be preferentially bound to red blood cells. It is excreted mainly unchanged in the urine. Hydrochlorothiazide crosses the placental barrier and is distributed into breast milk.
Register or sign in to continue
Asia's one-stop resource for medical news, clinical reference and education
Sign up for free
Already a member? Sign in