Full Prescribing Info
Vitamin B-complex, vitamin E.
Each tablet contains: d-Alpha Tocopheryl Acid Succinate (Vitamin E) 100 IU, Thiamine Mononitrate (Vitamin B1) 300 mg, Pyridoxine Hydrochloride (Vitamin B6) 100 mg, Cyanocobalamin (Vitamin B12) 1 mg.
This product contains B-complex vitamins (Vitamins B1, B6 and B12) and Vitamin E. B-complex vitamins are required for the normal function of the nervous system and are used as adjunct in the management of various neuromuscular disorders. Together with B-complex vitamins, Vitamin E helps maintain membrane integrity in all cells of the body including the nerve tissues by acting as the body's major lipid-soluble antioxidant. B-complex Vitamins and Vitamin E have the following known neuromuscular functions/effects: See table.

Click on icon to see table/diagram/image
For the treatment of deficiencies in Vitamins B1, B6, B12, and E manifested as: Abnormal touch sensation (numbness, glove and stocking sensation, burning and pricking); Muscle pain, loss of reflexes in the hands, knees, ankles, calves and feet.
For the treatment of conditions responsive to high dose Vitamins B1, B6, B12 and E which include the following: Polyneuropathy (multiple disturbances in the function of the brain or spinal cord that may affect the nerves and muscles of the body); Diabetic neuropathy (disturbances in the function of the brain or spinal cord that may affect the nerves and muscles of the body associated with diabetes mellitus); Neuralgia (nerve pain); Neuritis (inflammation of the nerves); Wernicke's disease (an alcohol-induced thiamine deficiency characterized by mental confusion, staggering, and constant rapid eye movements); Beriberi [Thiamine deficiency manifested as muscle weakness, loss of appetite, nerve degeneration (inability of nerves to function properly)]; Sideroblastic anemia (any of a heterogeneous group of anemias with diverse clinical manifestations); Pernicious anemia [a type of megaloblastic anemia usually seen in older adults, caused by impaired intestinal absorption of Vitamin B12 due to lack of availability of intrinsic factor characterized by pallor (paleness), achlorhydria (absence of hydrochloric acid from maximally stimulated gastric secretions), glossitis (inflammation of the tongue), weakness and neurologic manifestations].
Dosage/Direction for Use
Orally, one tablet daily.
Or, as directed by a doctor.
Missed Dose: If the patient missed a dose, just take the next dose and the subsequent doses at the usual recommended schedule, i.e., once a day.
Do not double the dose.
Signs and Symptoms of Overdosage: Vitamin B6: Cases have been reported of reversible sensory neuropathy developing at Pyridoxine doses less than 500 mg/day (dose range: 200-300 mg/day) taken for 36 months. Cases of reversible sensory peripheral neuropathy as a result of prolonged Pyridoxine use at a dose of 200 mg daily have also been reported.
If the patient has taken more than the recommended dosage, consult a doctor or contact a Poison Control Center right away.
If the patient is allergic to any component of the product.
Special Precautions
Do not take more than the recommended dose.
Consult the Doctor: Consult a doctor before using this product if the patient: has a history of stroke or risk factors for stroke; has any coagulation (blood clotting) problem or is taking anticoagulants (e.g., warfarin, aspirin, etc.).
If any undesirable effect occurs.
Adverse Reactions
Pyridoxine (Vitamin B6): Although Pyridoxine has generally been considered relatively non-toxic, adverse neurologic effects have been reported following chronic administration of high Pyridoxine doses (e.g., 100-500 mg daily) and long term (i.e., 2 months or longer) megadose (usually 2 g or more daily) Pyridoxine use.
d-Alpha Tocopheryl Acid Succinate (Vitamin E): Doses of Vitamin E greater than 1,000 mg (equivalent to 1,490 IU) per day have been associated with anticoagulant (blood thinning) effects.
Stroke with bleeding has been reported with high dose Vitamin E.
Drug Interactions
Neuromuscular blocking agents (e.g., Tubocurarine chloride, Metocurine iodide, Pancuronium bromide, and Vecuronium bromide) may be enhanced by high doses of Vitamin B1 (>500 mg daily), although the clinical significance of this is unknown.
Take this medicine (Neurogen-E) at least two hours before or after taking Phenobarbital or Phenytoin since high doses of Vitamin B6 may reduce the blood levels of these drugs.
Concomitant intake of anticoagulants (e.g., warfarin, aspirin, etc.) and Vitamin E may result in enhanced anticoagulant (blood thinning) response.
Store at temperatures not exceeding 30°C.
Protect from light.
MIMS Class
Vitamin B-Complex / with C
ATC Classification
A11EX - Vitamin B-complex, other combinations ; Used as dietary supplements.
Neurogen-E tab
100's (P1,400/box)
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