Nidcor Mechanism of Action





Full Prescribing Info
Pharmacology: Metformin improves glucose tolerance in patients with type 2 diabetes, lowering both basal and postprandial plasma glucose. Metformin decreases hepatic glucose production, decreases intestinal absorption of glucose, and improves insulin sensitivity by increasing peripheral glucose uptake and utilization. Metformin increases the body's sensitivity to insulin. It increases activity of insulin in fat and muscle tissues.
Pharmacokinetics: Metformin is well absorbed in the gastrointestinal tract. Metformin is not bound to plasma proteins.
Metformin is excreted unchanged in the urine and does not undergo hepatic metabolism. Following oral administration, approximately 90% of the absorbed drug is eliminated via the renal route within first 24 hours, with a half-life of approximately 2 hours.
In patients with decreased renal function, the plasma and blood half-life of metformin is prolonged and the renal clearance is decreased.
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