Orphenadrine citrate, paracetamol.
Each Norgesic tablet contains Paracetamol 450 mg, Orphenadrine citrate 35 mg.
Each Norgesic Forte tablet contains Paracetamol 650 mg, Orphenadrine citrate 50 mg.
Pharmacology: Pharmacokinetics: Orphenadrine is readily absorbed from the gastrointestinal tract and is almost completely metabolised to at least eight metabolites.
Orphenadrine and its metabolities are excreted from the body in the urine, with a half life of 14 hours.
Paracetamol is also readily absorbed from the gastrointestinal tract with peak plasma concentrations occurring about 10 to 60 minutes
after oral administration. Paracetamol is distributed into most body tissues. It has a half life of between 1 to 3 hours.
For the relief of painful skeletal muscle spasm associated with chronic low back pain, sprains and strains, prolapsed intervertebral disc, muscle injury, non-articular rheumatism (fibrositis, myositis and myalgia) whiplash injuries, acute torticollis, tension headache, dysmenorrhea and other acute or chronic painful muscular conditions.
Norgesic: 1-2 tablets three times a day or as prescribed by the physician.
Norgesic Forte: 1 tablet three times a day. In severe cases increase to a maximum of 2 tablets three times daily or as prescribed by the physician. Not recommended for children under the age of twelve.
Patients with glaucoma, prostatic hypertrophy or obstruction at the bladder neck or myasthenia gravis.
Orphenadrine may impair the ability of the patient to engage in potentially hazardous activities such as operating machinery or driving a motor vehicle.
Use with caution in patients with tachycardia, cardiac decompensation, coronary insufficiency, cardiac arrhythmias.
Safety of continuous long-term therapy with orphenadrine has not been established. If orphenadrine is prescribed for prolonged use, periodic monitoring of blood, urine and liver function is recommended.
Nausea, dry mouth, blurring of vision, dizziness and restlessness. Rarely, rash or drowsiness may occur. These symptoms disappear rapidly with a reduction in dosage or cessation of medication.
Amantadine, some antihistamines, butyrophenones and phenothiazines and tricyclic antidepressants may increase the antimuscarinic effects of orphenadrine. Orphenadrine may affect the absorption of other drugs.
Store at temperatures not exceeding 30°C.
M03BC51 - orphenadrine, combinations ; Belongs to the class of ethers. Used as centrally-acting muscle relaxants.
Norgesic: Tab 100's. Norgesic Forte: Tab 100's.