Norplus

Norplus

Manufacturer:

UNILAB, Inc

Distributor:

United Lab
Concise Prescribing Info
Contents
Imidapril HCl 10 mg, hydrochlorothiazide 12.5 mg
Indications/Uses
Dosage/Direction for Use
Initially, 1 tab once daily. Adjust dose based on clinical response.
Administration
May be taken with or without food.
Contraindications
History of angioneurotic edema; sulfonamide or thiazide hypersensitivity; renal failure anuria (CrCl <30 mL/min). Renovascular HTN. Pregnancy & lactation.
Special Precautions
Imidapril HCl: Na depletion or hypovolemia, dialysis, major surgery or during anesth. Unilateral or bilateral renal artery stenosis. Patients w/ renal function dependent on RAS eg heart failure. Hepatic disease. Gout or hyperuricemia. History of pancreatitis. Psoriasis, angioneurotic edema, hypersensitivity to insect toxins, anaphylactoid reactions during LDL-apheresis, aortic stenosis/hypertrophic cardiomyopathy, neutropenia, cough, hyperkalemia. 2nd & 3rd trimesters of pregnancy. Elderly w/ renal disease. Hydrochlorothiazide: Hypotension, fluid & electrolyte imbalance, hepatic or renal impairment, hypersensitivity reaction, SLE, metabolic & endocrine effects.
Adverse Reactions
Imidapril HCl: Cough, dizziness, hypotension, headache, strange sensation in pharynx & rash. Hydrochlorothiazide: Weakness; hypotension; pancreatitis, jaundice, diarrhea, vomiting, sialadenitis, cramps, constipation, gastric irritation, nausea & anorexia; hematologic & hypersensitivity reactions; electrolyte imbalance, hyperglycemia, glycosuria, hyperuricemia; muscle spasm; vertigo, paresthesia, dizziness, headache, restlessness; renal failure & interstitial nephritis; Stevens-Johnson syndrome, exfoliative dermatitis; impotence.
Drug Interactions
Imidapril HCl: Lithium; K-sparing diuretics, supplements, or salt substitutes; NSAIDs, antihypertensive agents, anesth drugs, narcotics, antipsychotics, allopurinol, cytostatic or immunosuppressive agents, systemic corticosteroids, procainamide, rifampicin, antidiabetics, antacids, sympathomimetics, alcohol. Hydrochlorothiazide: Alcohol, barbiturates, narcotics, amantadine, aminoglycosides, anticholinergics, antidiabetics, cholestyramine & colestipol resins, ACTH, cytotoxic agents, pressor amines, non-depolarizing skeletal muscle relaxants, lithium, NSAIDs including COX-2 inhibitors, other antihypertensive drugs.
ATC Classification
C09BA - ACE inhibitors and diuretics ; Used in the treatment of cardiovascular diseases.
Presentation/Packing
Form
Norplus tab
Packing/Price
100's (P2,688.25/pack, P26.88/tab)
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