General: As with other antibiotic preparations, prolonged use of this product may result in overgrowth of nonsusceptible organisms including fungi. If superinfection occurs, appropriate measures should be initiated.
Bacterial resistance to this product may also develop. If purulent discharge, inflammation or pain becomes aggravated, the patient should discontinue use of the medication and consult a physician.
Allergic cross-reactions may occur which could prevent the use of any or all of the following antibiotics for the treatment of future infections: kanamycin, paromomycin, streptomycin, and possibly gentamicin.
Information for Patients: Patients should be instructed to avoid allowing the tip of the dispensing container to contact the eye, eyelid, fingers, or any other surface. The use of this product by more than one person may spread infection.
Patient should also be instructed that ocular products, if handled improperly, can become contaminated by common bacteria known to cause ocular infections. If the condition persists or get worse, or if rash or other allergic reaction develops, the patient should be advised to stop use and consult a physician. Do not use this product if patient is allergic to any of the listed ingredients.
Keep tightly closed when not in use.
Use in Pregnancy: Teratogenic Effects: Pregnancy Category C: Adequate animal reproductive studies have not been conducted with neomycin, polymyxin B or gramicidin. It is also not known whether this product can cause fetal harm when administered to a pregnant women or can affect reproductive capacity. This product should be given to a pregnant woman only if clearly needed.
Use in Lactation: It is not known whether this drug is excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when this product is administered to a nursing woman.