Concomitant use of celecoxib and warfarin may result in increased risk of bleeding complications.
Concomitant use of celecoxib increases lithium plasma levels.
Concomitant use of celecoxib may reduce the antihypertensive effect of ACE Inhibitors and Angiotensin II Antagonist.
Use caution with drugs known to inhibit P450 2C9 or metabolized by 2D6 due to the potential for increased plasma levels.