Neuroleptic malignant syndrome & tardive dyskinesia may develop. History of seizures or w/ conditions that potentially lowers seizure threshold eg, Alzheimer's dementia; hepatic impairment, preexisting conditions associated w/ limited hepatic functional reserve, treatment w/ potentially hepatotoxic drugs. May induce orthostatic hypotension associated w/ dizziness, tachycardia, syncope especially during initial dose-titration period. Known CV (history of MI or ischemia, heart failure or conduction abnormalities) & cerebrovascular disease & conditions predisposing to hypotension (dehydration, hypovolemia & treatment w/ antihypertensives), experiencing conditions that may elevate or contribute to core body temp elevation eg, strenuous exercise, extreme heat exposure, concomitant use w/ anticholinergic activity or being subject to dehydration; at risk for aspiration pneumonia; significant prostatic hypertrophy, narrow-angle glaucoma, or history of paralytic ileus. Periodic assessment of transaminases in patients w/ hepatic disease. May be associated to esophageal dysmotility & aspiration. May impair ability to drive or operate machinery. Childn. Olandus 10
Pregnancy. Olandus ODT 15
Hyperglycemia & DM, lipid alteration, wt gain. Patients w/ low leukocyte &/or neutrophil counts for any reason, history of drug-induced bone marrow depression/toxicity, bone marrow depression caused by concomitant illness, radiation therapy or chemotherapy & hypereosinophilic conditions or myeloproliferative disease. Possibility of suicide attempt; not for dementia-related psychosis &/or behavioral disturbances; Parkinson's disease. Pregnancy & lactation. Elderly.