Olandus 5/Olandus 10/Olandus ODT 15

Olandus 5/Olandus 10/Olandus ODT 15

olanzapine

Manufacturer:

Cadila Healthcare

Distributor:

Metro Drug

Marketer:

Zydus Healthcare Phils
Concise Prescribing Info
Contents
Olanzapine
Indications/Uses
Olandus 5 Management of schizophrenia. Treatment of moderate to severe mania associated w/ bipolar disorder. Olandus 10 Management of manifestations of psychotic disorder eg, schizophrenia & short-term treatment of acute manic episodes associated w/ bipolar disorder. Olandus ODT 15 Short-term treatment of acute manic episodes associated w/ bipolar disorder. Schizophrenia. Prevention of recurrence in patients w/ bipolar disorder.
Dosage/Direction for Use
Olandus 5 tab Adult >18 yr Schizophrenia combination w/ mania, preventing recurrence in bipolar disorder 10 mg daily adjusted to 5-20 mg daily, doses >10 mg daily adjusted to 5-20 mg daily; doses >10 mg daily only after re-assessment. Max: 30 mg daily. Monotherapy for mania 15 mg daily adjusted to 5-20 mg daily, doses >15 mg only after re-assessment. Max: 20 mg daily. Olandus 10 tab Initially 10 mg daily as a single dose. Adjust dose by 5 mg daily at intervals of not <1 wk to w/in the range of 5-20 mg daily. Doses ≥15 mg daily should be given only after clinical re-assessment. Olandus ODT 15 OD tab Schizophrenia & related disorders 5-10 mg/day as a single daily dose. May be adjusted to 5-20 mg daily. May increase dose >10 mg/day only after appropriate clinical re-assessment. Acute mania associated w/ bipolar disorder 10 or 15 mg once daily as monotherapy or 10 mg once daily in combination therapy w/ lithium or valproate. Dose increments/decrement of 5 mg daily at interval of not <24 hr. Dose range: 5-20 mg/day. Max: 20 mg. Preventing recurrence in bipolar disorder 10 mg once daily. May be adjusted to 5-20 mg/day. Elderly, hepatic &/or renal impairment Starting dose: 5 mg/day.
Administration
May be taken with or without food: ODT 15 Tab: Place in the mouth & allow to dissolve completely then, swallow w/ saliva & follow w/ a glass of water. Alternatively, disperse in a full glass of water immediately prior administration.
Contraindications
Olandus 5 Hypersensitivity. Pregnancy & lactation. Olandus 10 Lactation. Olandus ODT 15 Hypersensitivity.
Special Precautions
Neuroleptic malignant syndrome & tardive dyskinesia may develop. History of seizures or w/ conditions that potentially lowers seizure threshold eg, Alzheimer's dementia; hepatic impairment, preexisting conditions associated w/ limited hepatic functional reserve, treatment w/ potentially hepatotoxic drugs. May induce orthostatic hypotension associated w/ dizziness, tachycardia, syncope especially during initial dose-titration period. Known CV (history of MI or ischemia, heart failure or conduction abnormalities) & cerebrovascular disease & conditions predisposing to hypotension (dehydration, hypovolemia & treatment w/ antihypertensives), experiencing conditions that may elevate or contribute to core body temp elevation eg, strenuous exercise, extreme heat exposure, concomitant use w/ anticholinergic activity or being subject to dehydration; at risk for aspiration pneumonia; significant prostatic hypertrophy, narrow-angle glaucoma, or history of paralytic ileus. Periodic assessment of transaminases in patients w/ hepatic disease. May be associated to esophageal dysmotility & aspiration. May impair ability to drive or operate machinery. Childn. Olandus 10 Pregnancy. Olandus ODT 15 Hyperglycemia & DM, lipid alteration, wt gain. Patients w/ low leukocyte &/or neutrophil counts for any reason, history of drug-induced bone marrow depression/toxicity, bone marrow depression caused by concomitant illness, radiation therapy or chemotherapy & hypereosinophilic conditions or myeloproliferative disease. Possibility of suicide attempt; not for dementia-related psychosis &/or behavioral disturbances; Parkinson's disease. Pregnancy & lactation. Elderly.
Adverse Reactions
Somnolence, wt gain. Olandus 5 Extrapyramidal symptoms including tardive dyskinesia; hyperprolactinemia (usually asymptomatic); increased appetite, peripheral edema, (rare) elevated creatine kinase conc. Olandus 10 Orthostatic hypotension. Olandus ODT 15 Asthenia, fatigue, wt gain; orthostatic hypotension; constipation, dry mouth, increased appetite; peripheral edema; eosinophilia.
Drug Interactions
May potentially induce hypotension w/ other centrally acting drugs & alcohol; enhance effects of certain antihypertensive agents. May antagonize the effects of levodopa & dopamine agonists. Metabolism may be mediated to some extent by CYP450 isozyme CYP1A2; concomitant use w/ drugs which inhibit or act as substrate to isozyme may affect plasma conc. May increase clearance by tobacco smoking. Olandus ODT 15 Concomitant use w/ medicine known to cause electrolyte imbalance or to increase QT interval. May induce metabolism by smoking or carbamazepine therapy. May decrease clearance w/ fluvoxamine or any other P450-1A2 inhibitor eg, ciprofloxacin.
MIMS Class
ATC Classification
N05AH03 - olanzapine ; Belongs to the class of diazepines, oxazepines and thiazepines antipsychotics
Presentation/Packing
Form
Olandus 5 FC tab 5 mg
Packing/Price
100's
Form
Olandus ODT 15 OD tab 15 mg
Packing/Price
100's
Form
Olandus 10 FC tab 10 mg
Packing/Price
100's (P150/film-coated tab)
Register or sign in to continue
Asia's one-stop resource for medical news, clinical reference and education
Sign up for free
Already a member? Sign in