Adult >18 yrSchizophrenia, combination therapy for mania, recurrence prevention in bipolar disorders 10 mg daily, may be adjusted to usual range of 5-20 mg daily. Give >15 mg dose only after reassessment. Max: 20 mg daily.
Enhanced central effects of CNS depressants including alcohol. May antagonize effects of dopaminergics. Neutropenia in concomitant use w/ valproate. May affect plasma conc w/ CYP1A2 inhibitors, inducers or substrates. Inhibited metabolism w/ fluvoxamine. Increased clearance w/ tobacco, smoking & carbamazepine.