Concise Prescribing Info
Pantoprazole Na sesquihydrate
Conditions where inhibition of gastric acid secretion maybe beneficial, including aspiration syndromes, dyspepsia, GERD, PUD & Zollinger-Ellison syndrome.
Dosage/Direction for Use
GERD 20-40 mg once daily for 4 wk. Dyspepsia 10-20 mg daily for 2-4 wk. PUD 20 mg daily as single dose, or 40 mg in severe cases. NSAID-associated ulceration 20 mg daily. Zollinger-Ellison syndrome 40 mg once daily. Acid aspiration prophylaxis during general anesth 40 mg in the evening before surgery & a further 40 mg 2-6 hr before the procedure.
May be taken with or without food: Swallow whole, do not chew/crush/split.
Special Precautions
Regularly monitor liver enzymes during treatment, particularly on long-term use in patients w/ severe liver impairment. Discontinue treatment in case of a rise in liver enzymes. Combination therapy. Exclude malignancy as treatment may alleviate symptoms & delay diagnosis. Not recommended w/ atazanavir. Patients w/ reduced body stores or risk factors for reduced vit B12 absorption on long-term therapy or observed respective clinical symptoms. Long-term treatment >1 yr. Slightly increased risk of GI infections caused by bacteria. Pregnancy & lactation.
Adverse Reactions
Headache, diarrhea & skin rashes. Pruritus, fatigue, constipation, nausea & vomiting, flatulence, abdominal pain, arthralgia & myalgia, urticaria & dry mouth. Increased risk of GI infections.
Drug Interactions
Reduction in absorption of ampicillin esters, iron salts or ketoconazole. Decreased hepatic metabolism resulting to delayed elimination & increased blood conc of anticoagulants (coumadin or indandione-derivative), diazepam or phenytoin. May increase leukopenic &/or thrombocytopenic effects of both pantoprazole Na sesquihydrate w/ bone marrow depressants.
MIMS Class
Antacids, Antireflux Agents & Antiulcerants
ATC Classification
A02BC02 - pantoprazole ; Belongs to the class of proton pump inhibitors. Used in the treatment of peptic ulcer and gastro-oesophageal reflux disease (GERD).
Opra-40 EC tab 40 mg
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