Shanxi Taisheng


Endure Medical
Full Prescribing Info
Oxacillin sodium.
Each vial contains: Oxacillin Sodium U.S.P. equivalent to Oxacillin 500 mg.
Pharmacology: Pharmacokinetics: Oxacillin Sodium is incompletely absorbed from the gastro-intestinal tract. Absorption is reduced by the presence of food in the stomach and is less than with cloxacillin. Peak plasma concentrations of 3 to 6 μg per mL have been achieved 1-hour after a dose of 500 mg given by mouth to fasting subjects.
Following the intramuscular injection of 500 mg peak plasma concentrations of up to 15 μg per mL have been achieved after 30 minutes. Doubling the dose can double the plasma concentration. About 93% of the Oxacillin in the circulation is bound to plasma protein. Oxacillin has been reported to have a plasma half-life of 0.5 to 1 hour. The half life is prolonged in neonates. The distribution of Oxacillin into body tissues and fluids is similar to the cloxacillin.
Oxacillin undergoes some metabolism, and the unchanged drug and metabolites are excreted in the urine by glomerular filtration and renal tubular secretion. About 20 to 30% of an oral dose and more than 40% of an intramuscular dose is rapidly excreted in the urine. Oxacillin is excreted in the bile.
Plasma concentrations are enhanced if probenecid is given.
Oxacillin is used in the treatment of infections due to staphylococci resistant to benzylpenicillin including bone and joint infections, endocarditis, peritonitis (associated with continuous ambulatory peritoneal dialysis), pneumonia, skin disorders (including soft-tissue infections), surgical infection (prophylaxis), and toxic shock syndrome.
Dosage/Direction for Use
Adult: 250 mg-2 g /dose every four (4) to six (6) hours through IM or IV push over 10 minutes or Intravenous infusion over 15-30 minutes.
Children: 100-200 mg/kg/day in divided doses every 6 hours IM or IV push over 10 minutes of Intravenous infusion over 15-30 minutes.
Meningitis: 200-400 mg/kg/day in divided doses every 6 hours. Maximum dose of 12 g/day Intramuscular/Intravenous. Doses may be increased in severe infections.
Direction for Reconstitution: For I.V. injection: add 3 mL sterile water for injection.
For I.M. injection: add 1.5 mL sterile water for injection and should be used immediately after reconstitution.
History of hypersensitivity to penicillin.
Special Precautions
Hepatitis and cholestatic jaundice have been reported occasionally with oxacillin and may be delayed in onset. Phlebitis has followed intravenous infusion. Oxacillin sodium has been reported to be incompatible with aminoglycosides and tetracyclines. Tetracyclines may antagonize the bactericidal effect of penicillin.
Adverse Reactions
Allergy, pseudomembranous colitis.
MIMS Class
ATC Classification
J01CF04 - oxacillin ; Belongs to the class of beta-lactamase resistant penicillins. Used in the systemic treatment of infections.
Powd for inj (vial) 500 mg x 10's.
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