Patients with Normal Kidney Function: Adults:
1-2 g IM/IV every 8 hrs; up to 12 g daily in severe infections.
Children and Older Infants:
20-40 mg/kg body weight every 6-8 hrs.
Neonates 1-4 weeks:
20-40 mg/kg body weight every 8 hrs; Neonates up to 1 week:
20-40 mg/kg body weight every 12 hrs.
In severe infections up to 200 mg/kg daily to maximum of 12 g daily.
Prophylaxis: Postoperative Surgical Infections: Adults:
2 g per IV route when inducing anesthesia, followed by injections of 1-2 g every 2 hrs until the skin has closed up. Antibioprophylaxis must be short; mostly limited to postoperation period, sometimes up to 24 hrs, but never exceeds 48 hrs.
Children and Infants:
30-40 mg/kg body weight every 6 hrs.
30-40 mg/kg interval of 8-12 hrs.
A single dose is sufficient.
1 g 2 times daily for IM.
Single dose of 2 g IM with probenecid 1 g by mouth.
A single 2-g dose may be given IV to the mother as soon as the umbilical cord is clamped.
IV route is recommended for children.
Patients with Renal Impairment: Adults:
Initial Dose: 1-2 g.
Maintenance: See table.
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Reconstitute the solution in 2 mL of water for injection.
Add 10 mL of water for injection. The solution can be administered by slow direct IV injection or through intermittent or continuous infusion.
The solution obtained after dilution in 10 mL of water for injection can be added to one of the following solutions which are of common use through infusion: 0.9% sodium chloride injection, 5% or 10% dextrose injection, dextrose and sodium chloride injection (5%/0.9%), 5% dextrose injection in a 0.02% sodium bicarbonate solution, 5% dextrose injection in a 0.02 or 0.45% saline solution, lactated Ringer's solution, 5% dextrose injection in lactated Ringer's solution, 5% or 10% invert sugar in water for injection, 10% invert sugar in saline solution, 5% sodium bicarbonate injection, M/6 sodium lactate injection.
Whatever the diluent and the administration route, all these preparations must be used immediately after reconstitution or dilution.