Pantor-20/Pantor-40

Pantor-20/Pantor-40

pantoprazole

Manufacturer:

Torrent

Distributor:

Torrent
Concise Prescribing Info
Contents
Pantoprazole Na sesquihydrate
Indications/Uses
Short-term treatment of erosive esophagitis associated w/ GERD. Maintenance of healing erosive esophagitis & reduction in relapse rates of daytime & nighttime heartburn symptoms in adults w/ GERD. Long-term treatment of pathological hypersecretory conditions including Zollinger-Ellison syndrome. Prophylaxis for NSAIDs-associated ulceration in patients w/ a need for continuous NSAID treatment, who have increased risk to develop NSAID-associated upper GI lesions. Eradication of H. pylori. PUD.
Dosage/Direction for Use
Short-term treatment of erosive esophagitis associated w/ GERD Adult 40 mg once daily up to 8 wk. An additional 8 wk for patients who have not healed after 8 wk of treatment. Childn ≥5 yr, >40 kg 40 mg, >15-<40 kg 20 mg once daily for up to 8 wk. Maintenance of healing erosive esophagitis & reduction in relapse rates of daytime & nighttime heartburn symptoms in GERD Adult 40 mg once daily. Long-term treatment of pathological hypersecretory conditions including Zollinger-Ellison syndrome Adult 40 mg bid. Prophylaxis for NSAIDs associated ulceration Adult 20 mg once daily. Eradication of H. pylori Pantoprazole 40 mg bid w/ clarithromycin 500 mg bid & either amoxicillin 1 g bid or metronidazole 400 mg bid. PUD 40 mg once daily usually given for 2-4 wk for duodenal ulceration, or 4-8 wk for benign gastric ulceration. Hepatic impairment Max: 20 mg daily, or 40 mg on alternate days. Renal impairment Max: 40 mg.
Administration
May be taken with or without food.
Contraindications
Hypersensitivity to pantoprazole Na or to any substituted benzimidazole.
Special Precautions
Symptomatic response to therapy does not preclude the presence of gastric malignancy. Atrophic gastritis in gastric corpus biopsies from patients on long-term therapy, particularly who were H. pylori +ve. Discontinue if acute interstitial nephritis develops. Prolonged use (eg, >3 yr) may lead to malabsorption of vit B12 caused by hypo- or achlorhydria. Clostridium difficile associated diarrhea. Increased risk for osteoporosis-related fractures of the hip, wrist, or spine. Monitor Mg levels prior to initiation of treatment & periodically. Concomitant use w/ methotrexate. Pregnancy & lactation.
Adverse Reactions
Headache, diarrhea, nausea, abdominal pain, vomiting, flatulence, dizziness & athralgia.
Drug Interactions
Decreased plasma conc of atazanavir or nelfinavir. Increased INR & prothrombin time w/ warfarin. Decreased absorption of ketoconazole, ampicillin esters, atazanavir, Fe salts, erlotinib & mycophenolate mofetil. False +ve urine screening tests for tetrahydrocannabinol. May elevate & prolong serum levels of methotrexate &/or its metabolite hydroxymethotrexate.
ATC Classification
A02BC02 - pantoprazole ; Belongs to the class of proton pump inhibitors. Used in the treatment of peptic ulcer and gastro-oesophageal reflux disease (GERD).
Presentation/Packing
Form
Pantor-40 EC tab 40 mg
Packing/Price
30's (P2,100/pack)
Form
Pantor-20 EC tab 20 mg
Packing/Price
30's (P1,500/pack)
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