Symptomatic response to therapy does not preclude the presence of gastric malignancy. Atrophic gastritis in gastric corpus biopsies from patients on long-term therapy, particularly who were H. pylori
+ve. Discontinue if acute interstitial nephritis develops. Prolonged use (eg, >3 yr) may lead to malabsorption of vit B12
caused by hypo- or achlorhydria. Clostridium difficile
associated diarrhea. Increased risk for osteoporosis-related fractures of the hip, wrist, or spine. Monitor Mg levels prior to initiation of treatment & periodically. Concomitant use w/ methotrexate. Pregnancy & lactation.