Sea King Pharma


Concise Prescribing Info
Pantoprazole Na sesquihydrate
GERD, peptic ulcer, for eradication of H. pylori (may be combined w/ 2 antibacterial in a 1-wk triple therapy regimen). Prophylaxis for NSAID-associated ulceration & treatment of pathological hypersecretory states eg, Zollinger-Ellison syndrome.
Dosage/Direction for Use
GERD 20-40 mg once daily for 4 wk, increased to 8 wk if necessary. For maintenance therapy, may be continued w/ 20-40 mg daily. PUD 40 mg once daily given for 2-4 wk for duodenal ulceration, or 4-8 wk for benign gastric ulceration. H. pylori eradication May be combined w/ 2 antibacterials in a 1-wk triple therapy regimen. Regimens may include pantoprazole 40 mg bid combined w/ clarithromycin 500 mg bid & either amoxicillin 1 g bid or metronidazole 400 mg bid.
Should be taken on an empty stomach: Take 1 hr before meals. Swallow whole, do not chew/crush.
Hypersensitivity. Concomitant use w/ atazanavir. Combination treatment for H. pylori in patient w/ moderate to severe hepatic or renal dysfunction.
Special Precautions
May mask symptoms & delay diagnosis of possibility of malignancy. Regularly monitor liver function. Not for mild GI complaints eg, nervous dyspepsia. Patient w/ reduced body stores or risk factors for reduced vit B12 absorption on long-term therapy. Hepatic impairment. Pregnancy & lactation. Not recommended in childn <12 yr.
Adverse Reactions
Headache, diarrhea. Rarely, nausea, upper abdominal pain, flatulence, constipation, skin rash, pruritus, or dizziness. Edema, fever, onset of depression, disturbances in vision, myalgia, elevated triglycerides, anaphylactic shock w/ symptoms of dizziness, rapid pulse or profuse sweating.
Drug Interactions
May alter metabolism of some other drugs metabolized by CYP450 system, primarily by isoenzyme CYP2C19. May prolong elimination of diazepam, phenytoin & warfarin. May reduce absorption of drugs eg, ketoconazole, & possibly itraconazole, whose absorption is dependent on acid gastric pH.
ATC Classification
A02BC02 - pantoprazole ; Belongs to the class of proton pump inhibitors. Used in the treatment of peptic ulcer and gastro-oesophageal reflux disease (GERD).
Pantovic EC tab 40 mg
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