Usual Dosage: 1 g/day as a single injection and up to 2 g/day as once-daily dose according to the severity of the infection and the patient's body weight.
2 g/day as a single injection. Usual therapy is 14 days long and can be up to 21 days long in severe or delayed forms of the disease.
Prophylaxis of Postsurgical Infections:
IV/IM injection of 1 g as a single dose when inducing anesthesia. The antibioprophylaxis must be of short duration and most often limited to the preoperative period, sometimes over 24 hrs. It shall never exceed 48 hrs.
Susceptibility to Purpura fulminans:
The 1st dose should be administered via IV route if possible, otherwise by IM route 1-2 g.
Children and Infants:
Usual Dosage: 50 mg/kg/day as a single injection.
50-100 mg/day as a single injection. Usual therapy is 14 days long and can be up to 21 days long in severe or delayed forms of the disease.
The dosage may vary from 50-100 mg/kg/day as a single injection, the dosage at 100 mg/kg is only justified as attack treatment. However, in the newborn from 3-12 months, injections every 12 hrs may be recommended because of a shorter plasma t½
Susceptibility to Purpura fulminans
: The 1st dose should be administered if possible through IV route, otherwise via IM route 50-100 mg/kg without exceeding 1 g.
Acute Otitis Media:
In case of therapeutic failure: 50 mg/kg/day for 3 days. In case of alternative treatment to oral treatment: 50 mg/kg as a single injection.
50 mg/kg as a single injection whatever the indication.
Recommended dosages are the same in elderly patients as in adults.
Ceftriaxone may be administered through IM or IV route: Reconstitute the solution with the appropriate diluent (water for injection for IV use, lidocaine for IM use) as given in the dilution table. Shake well until dissolved and then withdraw the entire contents of the vial into the syringe and use immediately. (See table.)
Click on icon to see table/diagram/image
Use the preparation immediately after reconstitution or dilution. Do not use lidocaine in case of allergy to lidocaine. Do not use lidocaine for IV administration.
The IV form may be used IM but the lidocaine solution is absolutely contraindicated through IV route. IM injection for babies is carried out in the antero-lateral part of the thigh. Do not inject >1 g at the same body site. The reconstituted solutions maintain potency for at least 6 hrs at room temperature (25±2°C) or at 24 hrs between 2-8°C.
Inject slowly over 2-4 min in the vein or through the tubing of an infusion. The reconstituted solutions maintain potency for at least 6 hrs at room temperature (25±2°C) or at 24 hrs between 2-8°C.
The infusion is about 30 min long. Two grams of ceftriaxone is dissolved in 40 mL of water for injection or in 40 mL of the following fluids commonly used for IV infusion: sodium chloride injection 0.9%, sodium chloride 0.45% + dextrose 2.5% solution, dextrose 5% solution, dextrose 10% solution, dextran 6% in dextrose 5% solution, hydroxyethylstarch 6-10%.