Panvell

Panvell

pantoprazole

Manufacturer:

PT Novell

Distributor:

Prosweal Healthcare
Concise Prescribing Info
Contents
Pantoprazole
Indications/Uses
Reflux esophagitis, gastric & duodenal ulcer, Zollinger-Ellison syndrome & other pathological hypersecretory conditions.
Dosage/Direction for Use
IV Reflux esophagitis, gastric & duodenal ulcer 40 mg/day. Zollinger-Ellison syndrome & other pathological hypersecretory conditions Initially, 80 mg/day, can be titrated as needed. Severe liver impairment Max: 20 mg/day.
Contraindications
Hypersensitivity to pantoprazole or substituted benzimidazoles.
Special Precautions
Monitor liver enzymes in long-term use. Concomitant use w/ atazanavir; vit B12. Increased risk of GI infections caused by Salmonella & Campylobacter or C. difficile. Monitor prothrombin time in concomitant use w/ phenprocoumon or warfarin. Risk of severe hypomagnesaemia; hip, wrist & spine fractures in older people w/ long term use (>1 yr). Pregnancy & lactation. Childn ≤18 yr.
Adverse Reactions
Benign fundic gland polyps, increased liver enzymes (transaminases, γ-GT).
Drug Interactions
May reduce absorption of drugs w/ a gastric pH-dependent bioavailability eg, azole antifungals (ketoconazole, itraconazole, posaconazole) & erlotinib. Substantial reduction in the bioavailability of HIV medications eg, atazanavir. Increased levels of methotrexate (at high dose eg, 300 mg). May reduce absorption of vit B12. Monitor prothrombin time/INR in patients treated w/ coumarin anticoagulants eg, phenprocoumon, warfarin.
ATC Classification
A02BC02 - pantoprazole ; Belongs to the class of proton pump inhibitors. Used in the treatment of peptic ulcer and gastro-oesophageal reflux disease (GERD).
Presentation/Packing
Form
Panvell powd for inj 40 mg
Packing/Price
1's
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