Penciclovir


Generic Medicine Info
Indications and Dosage
Topical/Cutaneous
Recurrent herpes simplex labialis
Adult: As 1% cream: Appy 2 hrly during waking hr (approx 8 times daily) for 4 days. Initiate treatment at earliest sign or symptom.
Child: >12 yr Same as adult dose.
Contraindications
Hypersensitivity to penciclovir, famciclovir.
Special Precautions
Immunocompromised patients (e.g. AIDS patients, bone marrow transplant recipients). Not recommended for application to mucous membranes (e.g. eyes, mouth, nose, genitals). Pregnancy and lactation.
Adverse Reactions
Headache, taste perversion, application site reactions (e.g. stinging, burning, numbness), pruritus, pain, rash, allergic reactions, contact dermatitis.
MonitoringParameters
Monitor reduction in virus shedding, negative cultures for herpes virus; resolution of pain and healing of cold sore lesion.
Action
Description: Penciclovir has in vitro and in vivo inhibitory activity against various Herpesviridae, including herpes simplex virus types 1 and 2 (HSV-1 and HSV-2), varicella zoster virus (VZV), and EpsteinBarr virus (EBV). In cells infected w/ HSV-1 or HSV-2, viral thymidine kinase phosphorylates penciclovir to a monophosphate form which, in turn, is converted to penciclovir triphosphate by cellular kinases. Penciclovir triphosphate inhibits HSV polymerase competitively w/ deoxyguanosine triphosphate. Consequently, herpes viral DNA synthesis and, therefore, replication are selectively inhibited.
Pharmacokinetics:
Absorption: Not absorbed appreciably into systemic circulation following topical administration at single or multiple doses up to a total of 180 mg (approx 67 times the proposed daily clinical dose).
Chemical Structure

Chemical Structure Image
Penciclovir

Source: National Center for Biotechnology Information. PubChem Database. Penciclovir, CID=135398748, https://pubchem.ncbi.nlm.nih.gov/compound/Penciclovir (accessed on Jan. 22, 2020)

Storage
Store between 20-25°C.
MIMS Class
References
Anon. Penciclovir. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 25/11/2014.

Buckingham R (ed). Penciclovir. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 25/11/2014.

Denavir Cream (Novartis Consumer Health Inc.). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 25/11/2014.

McEvoy GK, Snow EK, Miller J et al (eds). Penciclovir (Topical). AHFS Drug Information (AHFS DI) [online]. American Society of Health-System Pharmacists (ASHP). https://www.medicinescomplete.com. Accessed 25/11/2014.

Disclaimer: This information is independently developed by MIMS based on Penciclovir from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2021 MIMS. All rights reserved. Powered by MIMS.com
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