Cadila Healthcare


Metro Drug


Zydus Healthcare Phils
Concise Prescribing Info
Sildenafil citrate
Management of erectile dysfunction.
Dosage/Direction for Use
Erectile dysfunction 50 mg 1 hr before sexual intercourse. Dose may be increased or decreased depending on response. Max recommended dose is 100 mg & should not be taken >1 in 24 hr.
May be taken with or without food.
Hypersensitivity. Co-administration w/ nitric oxide donors (eg, amyl nitrite) or nitrates in any form. Men for whom sexual activity is inadvisable (eg, patients w/ severe CV disorders eg, unstable angina or severe cardiac failure). Loss of vision in 1 eye due to non-arteritic anterior ischemic optic neuropathy (NAION). Severe hepatic impairment, hypotension, recent history of stroke or MI & known hereditary degenerative retinal disorders (eg, retinitis pigmentosa); bleeding disorders, active peptic ulceration, HTN, MI or life-threatening arrhythmia.
Special Precautions
Patients w/ hepatic or severe renal impairment; anatomical deformation of the penis or hematological disorders that may predispose them to priapism. Monitor for prolonged erection (>4 hr). Discontinue if sudden visual or hearing loss occurs. May impair ability to drive or operate machinery. Elderly.
Adverse Reactions
Headache, flushing & dyspepsia. Visual disturbances eg, blurred vision, photophobia, chromatopsia, cyanopsia; eye irritation, pain & redness; retinal hemorrhage. Dizziness, insomnia, anxiety, vertigo, epistaxis, nasal congestion, pyrexia & GI disturbances (eg, diarrhea & vomiting). Cerebrovascular hemorrhage & transient ischemic attacks; palpitations, syncope, HTN, hypotension & serious CV events including MI, arrhythmias, tachycardia, unstable angina & sudden cardiac death.
Drug Interactions
May potentiate hypotensive effects of organic nitrates. Potentially enhance hypotensive effect of nicorandil. Risk of symptomatic hypotension w/ α-blockers. Clearance may be reduced by CYP3A4 inhibitors eg, cimetidine, delavirdine, erythromycin, itraconazole & ketoconazole. Increased plasma conc w/ HIV-PIs (particularly ritonavir-boosted regimens), grapefruit juice. Decreased plasma conc w/ CYP3A4 inducers eg, rifampicin. Reduced exposure by bosentan. Saquinavir, dihydrocodeine, tacrolimus.
ATC Classification
G04BE03 - sildenafil ; Belongs to the class of drugs used in erectile dysfunction.
Penegra FC tab 100 mg
100's (P85/box);4's
Penegra FC tab 50 mg
100's (P45/box);4's
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