Carefully observe for any changes in colour or temp of the skin in the extremities in patients w/ preexisting peripheral vascular disease eg, due to atherosclerosis, arterial embolism, Buerger's & Raynaud's disease, diabetic endarteritis or cold injury (eg, frostbite). Patients w/ cardiac ischaemia. May exacerbate pulmonary HTN. Decrease or suspend infusion rate if a disproportionate rise in the diastolic pressure (ie, marked decrease in the pulse pressure) is observed. Sulfite sensitivity especially in patients w/ asthma. Hypotension may occur when weaning patients from dopamine. Infuse into a large vein to prevent the possibility of extravasation. Fully correct hypovolaemia prior to treatment w/ a suitable plasma expander or whole blood or plasma. Correct acidosis, hypercapnia or hypoxia prior to or concurrently during treatment. Routine monitoring of BP, ECG, cardiac status & renal output is necessary. Should not be added to alkaline diluents. Concomitant use or w/in last 2-3 wk of MAOIs. Pregnancy & lactation. Not recommended for use in childn.