Pfizer Dopamine HCl

Pfizer Dopamine HCl





Concise Prescribing Info
Dopamine HCl
Correction of haemodynamic imbalance present in acute hypotension shock or shock associated w/ MI, endotoxic septicemia, trauma & renal failure; adjunct treatment after open heart surgery w/ persistent hypotension after correction of hypovolaemia; chronic cardiac decompression as in congestive failure.
Dosage/Direction for Use
Adult Start at 2-5 mcg/kg/min. Seriously ill patient Start at 5 mcg/kg/min & increase gradually by increments of 5-10 mcg/kg/min up to 20-50 mcg/kg/min as needed. Patient w/ cardiac decompensation Start at 1-2 mcg/kg/min. Patient w/ severe, refractory, chronic CHF Start at 0.5-2 mcg/kg/min, increasing dose as the urine flows increase to usual maintenance dose of 1-3 mcg/kg/min.
Phaeochromocytoma, atrial or ventricular tachyarrhythmias, hyperthyroidism. Concurrent use w/ cyclopropane, halogenated hydrocarbon anaesth & ergotamine.
Special Precautions
Carefully observe for any changes in colour or temp of the skin in the extremities in patients w/ preexisting peripheral vascular disease eg, due to atherosclerosis, arterial embolism, Buerger's & Raynaud's disease, diabetic endarteritis or cold injury (eg, frostbite). Patients w/ cardiac ischaemia. May exacerbate pulmonary HTN. Decrease or suspend infusion rate if a disproportionate rise in the diastolic pressure (ie, marked decrease in the pulse pressure) is observed. Sulfite sensitivity especially in patients w/ asthma. Hypotension may occur when weaning patients from dopamine. Infuse into a large vein to prevent the possibility of extravasation. Fully correct hypovolaemia prior to treatment w/ a suitable plasma expander or whole blood or plasma. Correct acidosis, hypercapnia or hypoxia prior to or concurrently during treatment. Routine monitoring of BP, ECG, cardiac status & renal output is necessary. Should not be added to alkaline diluents. Concomitant use or w/in last 2-3 wk of MAOIs. Pregnancy & lactation. Not recommended for use in childn.
Adverse Reactions
Ectopic beats, tachycardia, anginal pain, palpitation, hypotension, vasoconstriction; nausea, vomiting; headache; dyspnea.
Drug Interactions
May develop ventricular arrhythmias or HTN w/ cyclopropane &, halogenated anaesth. Potentiated effects & prolongs duration of action w/ MAOIs. Interfered adrenergic responses w/ α- & β-adrenergic blockers. Hypotension w/ vasodilators eg, glyceryl trinitrate, nitroprusside & Ca channel blockers. Blocked dopaminergic mediated renal vasodilation w/ large doses of butyrophenones. May potentiate CV effects resulting in arrhythmias, tachycardia, or severe HTN or hyperpyrexia w/ TCAs. May increase risk of cardiac arrhythmias w/ digitalis glycosides. Excessive vasoconstriction w/ methysergide or other ergot alkaloids. May potentiate pressor effect causing severe HTN & rupture of cerebral blood vessels w/ ergot alkaloids or oxytocin. Vascular ischaemia & gangrene w/ ergotamine. May potentiate pressor response w/ guanethidine. Dose dependency, sudden hypotension, bradycardia & possibly cardiac arrest w/ IV phenytoin. Other hydantoins. May interfere w/ urine tests of amino acids or catecholamines; tests for detecting uric acid or urobilinogen.
MIMS Class
Cardiac Drugs
ATC Classification
C01CA04 - dopamine ; Belongs to the class of adrenergic and dopaminergic cardiac stimulants excluding glycosides. Used in the treatment of hypotension.
Pfizer Dopamine HCl infusion 40 mg/mL
5 mL x 5 × 1's
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