Phenazone


Generic Medicine Info
Indications and Dosage
Oral
Mild to moderate pain
Adult: 500 mg to 1 g every 4-8 hr. Max: 4 g/day.
Child: 12-15 yr: 500 mg once or bid. Max: 1 g daily. >15 yr: 500 mg to 1 g every 4-8 hr. Max: 4 g/day.

Oral
Acute migraine attacks
Adult: 1 g every 4-8 hr. Max: 4 g/day.
Child: >15 yr: 1 g every 4-8 hr. Max: 4 g/day.

Otic/Aural
Otic inflammation, Removal of earwax
Adult: 4-6 drops (0.5% solution) 3-4 times daily depending on the severity of inflammation.
Contraindications
Allergy to pyrazolones or other NSAIDs. G6PD deficiency, porphyria. Otic/Aural: Perforated eardrums.
Special Precautions
Pregnancy. History of blood disorders.
Adverse Reactions
Hypersensitivity reactions, nephrotoxicity. Nausea, drowsiness, convulsive crisis, agranulocytosis, leucopenia.
Potentially Fatal: Coma (large oral doses), severe skin eruptions.
Drug Interactions
May affect metabolism of drugs metabolised by liver enzymes. Metabolism may be affected by liver enzyme inhibitors or inducers.
Action
Description: Phenazone is an NSAID.
Pharmacokinetics:
Absorption: Absorbed from the GI tract. Peak plasma concentrations within 1-2 hr.
Distribution: Throughout the body fluids; concentrations in the saliva and breast milk reaching about the same levels as those in plasma. Protein-binding: <10%.
Metabolism: Hepatic; metabolised to 3 major metabolites.
Excretion: Mainly via urine; via bile (small amount). Elimination half-life: About 12 hr.
Storage
Otic/Aural:
Store below 25°C.
Disclaimer: This information is independently developed by MIMS based on Phenazone from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2021 MIMS. All rights reserved. Powered by MIMS.com
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