Phil Pharmawealth Metformin HCl

Phil Pharmawealth Metformin HCl Mechanism of Action



Celogen Pharma


Endure Medical
Full Prescribing Info
Pharmacology: Pharmacokinetics: Metformin hydrochloride is slowly and incompletely absorbed from the gastrointestinal tract; the absolute bioavailability of a single 500 mg dose is reported to be about 50 to 60%, although this is reduced somewhat if taken with food. Once absorbed, protein binding in plasma is negligible; the drug is excreted unchanged in the urine. The plasma elimination half-life is reported to range from about 2 to 6 hours after oral doses. Metformin is distributed into breast milk in small amounts.
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