Each mL contains Dextrose 500 mg.
Glucose injection is used in the treatment of carbohydrate and fluid depletion. It is the preferred source of carbohydrate in parenteral nutrition regimens. It provides an available source of energy. Glucose is also used in the treatment of hypoglycemia.
Strongly hyperosmotic glucose solutions (50% solution) have been used to reduce cerebrospinal pressure and cerebral edema caused by delirium tremens or acute alcohol intoxication although they do not appear to be widely employed. Glucose solution 50% has also been used as a sclerosing agent in the treatment of varicose veins and as an irritant to produce adhesive pleuritis.
There is practically no limit to the amount of dextrose which may be given. The dose of glucose is variable and is dependent on individual patient requirements; serum-glucose concentrations may need to be carefully monitored. The maximum rate of glucose utilization has been estimated to be about 500 to 800 mg per kg body-weight per hour. In emergency treatment of hypoglycemia, it may be necessary to use a peripheral vein but the solution should be given slowly; a suggested rate for glucose 50% in such circumstances is 3 mL per minute. Or as prescribed by a physician.
The use of hyperosmotic glucose solution (50% solution) is contra-indicated in patients with anuria, intracranial or intraspinal hemorrhage, and in delirium tremens where there is dehydration. It is also contraindicated in glucose-galactose malabsorption syndrome. It has also been suggested that glucose solutions should not be used after acute ischemic strokes as hyperglycemia has been implicated in increasing cerebral ischemic brain damage and in impairing recovery.
Dextrose 50% solution should be administered with care to patients with diabetes insipidus.
Glucose solutions should not be administered through the same infusion equipment as whole blood as hemolysis and clumping can occur.
Intravenous administration of glucose solutions particularly hyperosmotic solution, which also have a low pH may cause local pain, vein irritation, and thrombophlebitis, and tissue necrosis if extravasation occurs. Some of these reactions may be due to degradation products present after autoclaving or to poor administration technique. Intravenous infusion can lead to the development of fluid and electrolyte disturbances including hypokalemia, hypomagnesemia and hypophosphatemia. Prolonged administration or rapid infusion of large volumes of iso-osmotic solutions may cause edema or water intoxication; conversely, prolonged or rapid administration of hyperosmotic solutions may result in dehydration as a consequence of the induced hyperglycemia.
Store at temperatures not exceeding 30°C.
B05AA05 - dextran ; Belongs to the class of blood substitutes and plasma protein fractions. Used as blood substitutes.
Soln for inj (amp) 50% x 50 mL x 1's.