Magnesium Sulfate maybe administered by Intramuscular or direct Intravenous Injection, IV infusion, or addition to and auxiliary medication infusion unit. For Intravenous Injection, a concentration of 20% or less should be used; the rate of injection should not exceed 1.5 mL of a 10% w/v solution or equivalent per minute. For Intramuscular Injection a 25% concentration is satisfactory for adults but dilution to 20% is recommended for children.
The dosage of Magnesium Sulfate should be individualized based on patient's needs and response.
In the management of eclampsia or severe pre-eclampsia, and initial dose of 4 g by I.V. Infusion along with 4 or 5 grams intramuscular into each buttock has been recommended. This dose if forward by intramuscular doses of 4 to 5 g in alternate buttocks at 4 hours interval as needed. Total dosage should not exceed 30 to 40 g daily.
For mild magnesium, the usual adult dose is 1 g Intramuscular every 6 hours for 4 doses.
As anticonvulsant, the usual adult dose is 1 g administered intravenously or muscularly.
In adult with severe renal impairment, the dosage should not exceed 20 g in 48 hours.