Piperacillin sodium and Tazobactam sodium injection should be administered by intravenous infusion over 30 minutes.
The usual total daily dose of Piperacillin sodium and Tazobactam sodium injection for adults is 3.375 g every six hours totaling 13.5 g (12 g piperacillin sodium/1.5 g tazobactam sodium).
Initial presumptive treatment of patients with nosocomial pneumonia should start with Piperacillin sodium and Tazobactam sodium injection at a dosage of 4.5 g every six hours plus an aminoglycoside, totaling 18.0 g (16.0 g piperacillin sodium/2.0 g tazobactam sodium). Treatment with the aminoglycoside should be continued in patients from whom Pseudomonas aeruginosa is isolated. If Pseudomonas aeruginosa is not isolated, the aminoglycoside may be discontinued at the discretion of the treating physician.
Renal Insufficiency: In patients with renal insufficiency (Creatinine Clearance ≤ 40 mL/min), the intravenous dose of Piperacillin sodium and Tazobactam sodium injection (piperacillin and tazobactam injection) should be adjusted to the degree of actual renal function impairment. In patients with nosocomial pneumonia receiving concomitant aminoglycoside therapy, the aminoglycoside dosage should be adjusted according to the recommendations of the manufacturer. The recommended daily doses of Piperacillin sodium and Tazobactam sodium injection for patients with renal insufficiency are as follows: see table.
Click on icon to see table/diagram/image
For patients on hemodialysis, the maximum dose is 2.25 g every twelve hours for all indications other than nosocomial pneumonia and 2.25 g every eight hours for nosocomial pneumonia. Since hemodialysis removes 30% to 40% of the administered dose, an additional dose of 0.75 g Piperacillin sodium and Tazobactam sodium injection should be administered following each dialysis period on hemodialysis days. No additional dosage of Piperacillin Na & Tazobactam Na (Pipzo) is necessary for CAPD patients.
Duration of Therapy: The usual duration of Piperacillin sodium and Tazobactam sodium injection treatment is from seven to ten days. However, the recommended duration of Piperacillin sodium and Tazobactam sodium injection treatment of nosocomial pneumonia is 7 to 14 days.
In all conditions, the duration of therapy should be guided by the severity of the infection and the patient's clinical and bacteriological progress.
Directions for Reconstitution and Dilution for Use: Intravenous Administration: 2.25 g, 3.375 g, and 4.5 g Piperacillin sodium and Tazobactam sodium for injection should be reconstituted with Sterile Water for Injection 10 mL, 15 mL, and 20 mL, respectively. Swirl until dissolved.
Reconstitution diluents: IV Injection: Sterile water for Injection, 0.9% Sodium Chloride, Dextrose 5%.
IV Infusion: 0.9% Sodium Chloride, Dextrose 5% in water, Dextran 6% in saline, Sterile water for Injection.