insulin glargine




Concise Prescribing Info
Insulin glargine
DM where treatment w/ insulin is required in adult, adolescent & childn ≥2 yr.
Dosage/Direction for Use
SC Individualized dosage. Administer once daily at the same time everyday. Dose & timing should be individually adjusted. Type 2 diabetes on oral antidiabetic agents Initially 10 IU once daily & subsequently adjusted individually.
Special Precautions
Not for the treatment of diabetic ketoacidosis. Hypoglycemia. Intercurrent illness. Renal & severe hepatic impairment. Monitor blood glucose regularly & require intensified metabolic monitoring. May impair ability to drive or operate machinery. Pregnancy & lactation. Childn <2 yr. Elderly.
Adverse Reactions
Hypoglycemia, temporary visual impairment, lipodystrophy, inj site & allergic reactions (eg, redness, pain, itching, hives, swelling & inflammation).
Drug Interactions
May increase blood glucose lowering effect & susceptibility to hypoglycemia w/ oral antidiabetic products, ACE inhibitors, salicylates, disopyramide, fibrates, fluoxetine, MAOIs, pentoxifylline, propoxyphene, sulfonamides. May reduce blood lowering effect w/ corticosteroids, danazol, diazoxide, diuretics, sympathomimetic agents (eg, epinephrine, salbutamol, terbutaline), glucagon, INH, phenothiazine derivates, somatropin, thyroid hormones, estrogens, progestogens (eg, OCs), PIs & atypical antipsychotic medications (eg, olanzapine & clozapine). Potentiated or weakened blood glucose lowering effect w/ β-blockers, clonidine, lithium salts & alcohol. Pentamidine may cause hypoglycemia, (sometimes) followed by hyperglycemia. Reduced or no signs of adrenergic counter regulation w/ β-blockers, clonidine, guanethidine & reserpine.
ATC Classification
A10AE04 - insulin glargine ; Belongs to the class of long-acting insulins and analogues for injection. Used in the treatment of diabetes.
Podevta soln for inj 100 u/mL
(w/ 3 mL cartridge) 5 × 1's (P3,717.86/box)
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