Generic Medicine Info
Indications and Dosage
Anogenital warts
Adult: As 0.5% gel: Apply bid for 3 days; if needed, repeat at weekly intervals for 4 or 5 weeks treatment. Max: 0.5 g daily or ≤10 cm2 of wart tissue.
Child: >12 years Same as adult dose.

Condyloma acuminata
Adult: For cases affecting the external genitals: As 0.15% cream or 0.5 % solution: Apply bid for 3 days; if needed, repeat at weekly intervals for 4 weeks. Max (0.5% solution): 0.5 mL daily or ≤10 cm2 of wart tissue.
Broken skin. Children <12 years. Pregnancy and lactation.
Special Precautions
Adverse Reactions
Significant: Application site reactions (e.g. irritation, inflammation, burning sensation, erythema, pruritus, bleeding), erosion.
GI disorders: Vomiting.
Nervous system disorders: Headache, dizziness.
Psychiatric disorders: Insomnia.
Renal and urinary disorders: Haematuria.
Reproductive system and breast disorders: Balanoposthitis.
Vascular disorders: Bleeding.
Patient Counseling Information
Avoid use of occlusive dressing or wrappings. Avoid contact with eyes and mucous membranes (e.g. genital area). Topical gel and solution is flammable, avoid exposure to excessive heat and flame. Refrain from engaging in sexual activity on days during treatment.
Symptoms: Nausea, vomiting, abdominal pain, diarrhoea, hepatotoxicity, renal failure, thrombocytopenia, leucopenia; delayed CNS-related effects including acute psychotic reactions, hallucinations, confusion, dizziness, stupor, ataxia, hypotonia, seizures, coma; delayed peripheral neuropathies resulting to paraesthesias, reduced reflexes, muscle weakness, tachycardia, apnoea, orthostatic hypotension, paralytic ileus, urinary retention. Management: Symptomatic and supportive treatment. Wash off from the application area.
Description: Podophyllotoxin is a keratolytic with an antimitotic action. It binds to the microtubule protein of the mitotic spindle thereby inhibiting metaphase and leading to cell death and necrosis of wart tissue.
Absorption: Absorbed through the skin or mucous membranes. Time to peak plasma concentration: 1-2 hour.
Excretion: Plasma elimination half-life: 1- 4.5 hour.
Chemical Structure

Chemical Structure Image

Source: National Center for Biotechnology Information. PubChem Database. Podofilox, CID=10607, https://pubchem.ncbi.nlm.nih.gov/compound/Podofilox (accessed on Jan. 23, 2020)

Store between 20-25°C. Protect from excessive heat and open flames.
MIMS Class
Warts & Calluses Preparations
ATC Classification
D06BB04 - podophyllotoxin ; Belongs to the class of topical antivirals used in the treatment of dermatological diseases.
Anon. Podofilox. AHFS Clinical Drug Information [online]. Bethesda, MD. American Society of Health-System Pharmacists, Inc. https://www.ahfscdi.com. Accessed 23/11/2017.

Anon. Podofilox. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 23/11/2017.

Buckingham R (ed). Podophyllum. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 23/11/2017.

Condylox Gel (Actavis Pharma, Inc.). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 23/11/2017.

Joint Formulary Committee. Podophyllotoxin. British National Formulary [online]. London. BMJ Group and Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 23/11/2017.

Podofilox Solution (Actavis Pharma, Inc.). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 23/11/2017.

Disclaimer: This information is independently developed by MIMS based on Podophyllotoxin from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2022 MIMS. All rights reserved. Powered by MIMS.com
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