Pharmacology:Pharmacokinetics: Both Piperacillin and Tazobactam are not well absorbed in the GIT but have a good bioavailability after an IM injection. They are both widely distributed into different body compartments but penetration into the meninges of Tazobactam is poor when meninges are inflamed. Tazobactam is metabolized to a single inactive metabolite while Piperacillin is metabolized to the desethyl metabolite, which has minor activity. Approximately 68% and 80% of an administered dose of Piperacillin and Tazobactam, respectively are excreted unchanged in the urine.
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