Adverse reactions to PROFUREX have occurred relatively infrequent and have been generally mild and transient in nature. Effects reported include rashes, gastrointestinal disturbances and candida intertrigo.
The principal changes in hematological parameters seen in some patients are decreased hemoglobin concentration and eosinophilia.
A positive Coomb's test has been found in some patients treated with cefuroxime- this phenomenon can interfere with the crossmatching of blood.
Although there are sometimes transient increases in serum liver enzymes and serum bilirubin, particularly in patients with pre-existing liver disease, there is.no evidence of hepatic involvement.
There may also be some variation in the results of biochemical tests of renal function, but these do not appear to be of clinical importance. As a precaution, renal functions should be monitored if this is already impaired.
Transient pain may be experienced at the site of intramuscular injection. This is more likely to occur with higher doses. However, it is unlikely to be a cause for discontinuation of treatment.