Profurex Dosage/Direction for Use





Cathay Drug
Full Prescribing Info
Dosage/Direction for Use
General Dosage Recommendations: Adults: Many infections will respond to 750 mg every 8 hours by intramuscular or intravenous injection. For more severe infections, this dose may be increased to 1.5 g every 8 hours intravenously. The frequency of intramuscular or intravenous injections can be increased to six-hourly if necessary, giving a total dose of 3 to 6 g daily.
Infants and children: Doses of 30 to 100 mg/kg/day, given as three or four divided doses. A dose of 60 mg/kg/day will be appropriate for most infections.
Neonates: Doses of 30 to 100 mg/kg/day, given as two or three divided doses. In the first week of life, the serum half-life of cefuroxime can be three to five times that in adults.
Other Recommendations: Prophylaxis: The usual dose is 1.5 g IV with induction of anesthesia for abdominal, pelvic and orthopedic surgeries, but may be supplemented with two 750 mg IM doses 8 and 16 hours later. In cardiac, pulmonary, esophageal and vascular surgeries, the usual dose is 1.5 g IV with induction of anesthesia. continuing with 750 mg IM every 8 hours for a further 24 to 48 hours.
Total joint replacement: 1.5 g cefuroxime powder may be mixed dry with each pack of methylmethacrylate cement monomer before adding the liquid monomer.
Gonorrhea: 1.5 g cefuroxime should be given as a single dose. This may be given as 2x750 mg injection into different sites, e.g. each buttock.
Dosage in impaired renal function: Cefuroxime is excreted by the kidneys. Therefore, as with all such antibiotics, in patients with impaired renal function it is recommended that the dosage of PROFUREX be reduced to compensate for its slower excretion, except in mild impairment; (GFR>50 mL/min.). In adults with moderate impairment (GFR20-50 mL/min.) only 750 mg every 8 hours is required with marked impairment (GFR10-20 mL/min.) 750 mg every 12 hours is sufficient; and with severe impairment (GFR<10 mL/min.) 750 mg once daily is adequate. For patients on dialysis, a further 750 mg dose should be given at the end of each dialysis.
Administration: Intramuscular: Add 1 mL Water for Injection for 250 mg PROFUREX or 3 mL Water for Injection to 750 mg PROFUREX.
Shake gently to produce an opaque suspension.
Intravenous: Dissolve PROFUREX in Water for Injection using at least 2 mL for 250 mg, at least 6 mL for 750 mg or 15 mL for 1.5 g.
For short intravenous infusion (e.g. up to 30 minutes) 1.5 g may be dissolved in 50 mL Water for Injection.
These solutions may be given directly into the vein or introduced into the tubing of the giving set if the patient is receiving parenteral fluids.
PROFUREX is compatible with the more commonly used intravenous fluids.
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