Pharmacology: Pharmacodynamics: PROFUREX is a bactericidal cephalosporin antibiotic which is resistant to most β-lactamases and is active against a wide range of gram-positive and gram-negative organisms. It is indicated for the treatment of infections caused by sensitive bacteria. In addition, it is an effective prophylactic agent against post-operative infection in a variety of operations. Usually, it will be effective alone, but when appropriate, it may be used in combination with an aminoglycoside antibiotic or in conjunction with metronidazole, orally or by suppository or injection especially for prophylaxis in colonic surgery (see Cautions for Usage).
Microbiology: Bacteriology: PROFUREX is highly active against Staphylococcus aureus, including strains which are resistant to penicillin (but not the rare methicillin-resistant strains); Staphylococcus epidermidis, Haemophilus influenzae, Klebsiella spp., Enterobacter spp., Streptococcus pyogenes, Escherichia coli, Streptococcus mitis (viridans group), Clostridium spp., Proteus mirabilis, Proteus rettgeri, Salmonella typhi, Salmonella typhimurium, and other Salmonella spp., Shigella spp., Neisseria spp., (including 6-lactamase producing strains of N. gonorrheae) and Bordetella pertussis. It is also moderately active against strains of Proteus vulgaris, Proteus morgani, and Bacteroides fragilis.
In vitro, the activity of PROFUREX and aminoglycoside antibiotics in combination have been shown to be at least additive with occasional evidence of synergy.