Cephalosporin antibiotics may, in general, be given safety to patients who are hypersensitive to penicillins, although cross reactions have been reported. Special care is indicated in patients who have experienced an anaphylactic reaction to penicillin.
Cephalosporin antibiotics at high dosage should be given with caution to patients receiving concurrent treatment with potent diuretics such as furosemide as these combinations are suspected of adversely affecting renal function. Clinical experience with PROFUREX has shown that this is not likely to be a problem at the recommended dose levels. There is no experimental evidence of embryonic or teratogenic effects attributable to PROFUREX, but as with all drugs, it should be administered with caution during the early months of pregnancy.
PROFUREX does not interfere in the enzyme-based tests for glycosuria. Slight interference with copper reduction methods (Benedict's, Fehlings, Clinitest) may be observed. However, this should not lead to false-positive results, as may be experienced with some other cephalosporins.
PROFUREX may cause false-negative reactions in the ferricyanide test. Some cephalosporins can cause a falsely high reading in the alkaline picrate assay for creatinine, although the degree of elevation is unlikely to be of clinical importance. It is possible that cefuroxime may also interfere with this determination.
As with other antibiotics, prolonged use may result in the over-growth of non-susceptible organisms.