Psynor

Psynor

chlorpromazine

Manufacturer:

Swiss Pharma

Distributor:

PHARMASIA
Concise Prescribing Info
Contents
Chlorpromazine HCl
Indications/Uses
Excessive anxiety, tension & agitation; nausea, vomiting & intractable hiccups, cancer & severe pain to reduce apprehension, suffering & to reduce narcotic requirements. Control of acute intermittent porphyria & adjunct in the treatment of tetanus. Management of the manifestations of psychotic disorders; control of involutional melancholia or manifestations of manic-depressive illness; control of moderate to severe agitation, hyperacidity or aggressiveness in disturbed childn.
Dosage/Direction for Use
Excessive anxiety, tension & agitation Adult 10 mg tid-qid or 25 mg bid-tid. More severe cases 25 mg tid. After 1 or 2 days, increase dose by 20-50 mg at semi-wkly intervals until patient is calm. Continue optimum dose for 2 wk then gradually reduce to maintenance level. Nausea & vomiting Adult 10-25 mg 4-6 hrly. Childn ¼ mg/lb 4-6 hrly. Intractable hiccups 25-50 mg tid-qid. Alcohol w/drawal (agitated but manageable) 50 mg followed by 25-50 mg tid. Ambulatory patient w/ w/drawal symptoms 10 mg tid-qid or 25 mg bid-tid. Pre-op surgery Adult 25-50 mg 2-3 hr before operation. Childn ¼ mg/lb 2-3 hr before operation. Psychiatric disorders Adult: Outpatient 10 mg tid-qid or 25 mg bid-tid. More severe cases 25 mg tid. After 1 or 2 days, increase dose by 20-50 mg at semi-wkly intervals until patient becomes calm & cooperative. Hospitalized patient: Less acutely agitated 25 mg tid; increase gradually until effective dose is needed, usually 400 mg daily. Childn: Outpatient ¼ mg/lb 4-6 hrly. Hospitalized patient Start w/ low doses & increase gradually. Severe personality & behavioural disorders or psychotic conditions 50-100 mg daily & in older childn ≥200 mg daily.
Administration
May be taken with or without food: May be taken w/ meals to reduce GI discomfort.
Contraindications
Comatose states, presence of large amount of CNS depressants (alcohol, barbiturates, narcotics), bone marrow depression.
Special Precautions
Hypersensitivity. CV or liver disease, chronic resp disorders (eg, severe asthma, emphysema & acute resp infections particularly in childn). Persons exposed to extreme heat, organophosphorus insecticides & those receiving atropine or related drugs. Pregnancy.
Adverse Reactions
Drowsiness; jaundice, agranulocytosis, EKG changes, neuromuscular extrapyramidal reactions, persistent dyskinesia, lactation & moderate breast engorgement, amenorrhea, gynecomastia, hyperglycemia & glycosuria; dry mouth, nasal congestion, constipation, adynamic ileus, miosis & mydriasis; skin pigmentation, ocular changes.
Drug Interactions
Additive effect when used w/ alcohol. Counteracts effects of guanethidine & related compd. Prolongs & intensifies action of CNS depressants (eg, anesth, barbiturates & narcotics).
MIMS Class
ATC Classification
N05AA01 - chlorpromazine ; Belongs to the class of phenothiazine antipsychotics with aliphatic side-chain.
Presentation/Packing
Form
Psynor tab 100 mg
Packing/Price
100's
Form
Psynor tab 200 mg
Packing/Price
100's
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