Adjust dosage to individual and the severity of condition. It is important to increase dosage until symptoms are controlled. Dosage should be increased more gradually in elderly and emaciated patients. In continued therapy, gradually reduce dosage to the lowest effective maintenance level.
General Medicine: Adults: Excessive Anxiety, Tension and Agitation: 10 mg 3 or 4 times a day or 25 mg 2 or 3 times a day.
More Severe Cases: 25 mg 3 times a day. After 1 or 2 days, daily dosage may be increased by 20-50 mg semi-weekly, until patient becomes calm and cooperative. (Maximum improvement may not be seen for weeks or even months).
Continue optimum dosage for 2 weeks; then gradually reduce to maintenance level. Daily dosage of 200 mg is not usual.
Some patients require higher dosages (e.g. 800 mg daily is not uncommon in discharged mental patients).
Nausea and Vomiting: 10-25 mg every 4-6 hours.
Intractable Hiccups: 25-50 mg 3 or 4 times a day.
Alcohol Withdrawal: Agitated but Manageable: 50 mg followed by 25-50 mg 3 times a day.
Ambulatory patients with withdrawal symptoms: 10 mg 3 or 4 times a day; or 25 mg 2 or 3 times a day.
Children: Nausea and Vomiting: Chlorpromazine should not be used in conditions for which specific children's dosages have not been established. Oral: 1/4 mg/lb body weight every 4-6 hours.
Surgery: Adults: Preoperative: 25-50 mg, 2-3 hours before the operation.
Children: Preoperative: 1/4 mg/lb body weight, 2-3 hours before operation.
Psychiatry: Adults: Office Patients or Outpatients: 10 mg 3 or 4 times a day or 25 mg 2 or 3 times a day.
More Severe Cases: 25 mg 3 times a day. After 1 or 2 days, daily dosage may be increased by 20-50 mg at semi-weekly intervals until patient becomes calm and cooperative.
Hospitalized Patients: Less Acutely Agitated: 25 mg 3 times a day. Increase gradually until effective dose is reached, usually 400 mg daily.
Children: Office Patients or Outpatients: 1/4 mg/lb body weight every 4-6 hours, if necessary.
Hospitalized Patients: Start with low doses and increase dosage gradually. In severe personality and behavior disorders or psychotic conditions, higher dosages (50-100 mg daily, and in older children, 200 mg daily or more) may be necessary or as prescribed by the physician.