Symptoms: 1 of 3 clinical pictures may be seen: Extreme Somnolence: Patient can usually be roused with prodding, but if permitted will fall asleep. General condition is usually satisfactory, skin, though pale, is warm and dry. Slight blood pressure, respiratory and pulse changes may occur but are not problems.
Mild to moderate drop in blood pressure (whether conscious or unconscious). Skin is markedly gray but warm and dry. Nail beds are pink. Respiration is slow and regular. Pulse is strong but rate slightly increased.
Severe hypotension, possibly accompanied by weakness, cyanosis, perspiration, rapid thready pulse and respiratory depression.
Treatment: Essentially symptomatic and supportive. Early gastric lavage and intestinal purges may help. Centrally-acting emetics will not help because of the antiemetic effect of Chlorpromazine. Severe hypotension usually responds to measures described under hypotensive effects. Additional measures include pressure bandages to lower limbs, oxygen, and IV fluids. If stimulant is desired, use amphetamine, dextroamphetamine, or caffeine and sodium benzoate.
Avoid stimulants that may cause convulsions (eg, picrotoxin and pentylenetetrazol).
Limited experience with dialysis indicates that it is not helpful.