Patients who have demonstrated a hypersensitivity reaction should not be re-exposed to any phenothiazine, including Chlorpromazine, unless in the judgment of the physician, the potential benefits of treatment outweight the possible hazard. Chlorpromazine should be administered cautiously to patients with cardiovascular or liver disease. Because of its CNS depressant effect, it should be used with caution in patients with chronic respiratory disorders e.g. severe asthma, emphysema and acute respiratory infections, particularly in children. Use with caution in persons who will be exposed to extreme heat organophosphorus insecticides, and in persons receiving atropine or related drugs. The use of Chlorpromazine during pregnancy has not been established.