Control of acutely agitated schizophrenic patient w/ moderate to very severe symptoms 2-5 mg IM every 4-8 hr depending on the response, may be administered as often as every hr. Max: 20 mg/day.
Caution when in concomitant w/ medications known to prolong the QT-interval or known to cause electrolyte imbalance. If concomitant w/ antiparkinsonism medication, it may be continued after haloperidol is discontinued due to differences in excretion rates. Potentiates CNS depressants eg, anesth, opiates & alcohol. Increased QTc w/ metabolic inhibitors ketoconazole (400 mg/day) & paroxetine (20 mg/day). Increased conc w/ CYP3A4 or CYP2D6 inhibitors eg, itraconazole, nefazodone, buspirone, venlafaxine, alprazolam, fluvoxamine, quinidine, fluoxetine, sertraline, chlorpromazine, & promethazine. Reduced plasma levels w/ enzyme-inducing drugs eg, rifampin or carbamazepine.
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