Pulmoxcel

Pulmoxcel Mechanism of Action

terbutaline

Manufacturer:

GXI

Distributor:

Metro Drug
Full Prescribing Info
Action
Pharmacology: Pharmacodynamics: PULMOXCEL is a brand of Terbutaline sulfate, a direct-acting sympathomimetic agent with predominantly beta-adrenergic activity and a selective action on β2-receptors. It is used as bronchodilator by stimulating β2-adrenergic receptors in the lungs to relax bronchial smooth muscle thereby relieving bronchospasm, increasing vital capacity, decreasing residual volume and reducing airway resistance.
TERBUTALINE sulfate has more prolonged actions than other sympathomimetic agent isoprenaline, its bronchodilating action being relatively more prominent than its effect on the heart. It also mediates in decreasing gastrointestinal tone and increases uterine muscle relaxation.
Pharmacokinetics: Tablet & Syrup: TERBUTALINE undergoes extensive first-pass metabolism by sulfate (and some glucuronide) conjugation in the liver and the gut wall. It is excreted in the urine and faeces partly as the inactive sulfate conjugate and partly as unchanged terbutaline, the ratio depending upon the route by which it is given. The terminal half-life after single and multiple dosing is reported to be between 16 and 20 hours.
Nebulizing solution: On inhalation of terbutaline, less than 10% of the drug is absorbed from the airways. The remainder is swallowed where it is variably absorbed from the gastrointestinal tract. Fasting bioavailability after oral doses is reported to be about 14 to 15% and is reduced by food. Terbutaline undergoes extensive first-pass metabolism by sulfate (and some glucuronide) conjugation in the liver and the gut wall. It is excreted in the urine and faeces partly as the inactive sulfate conjugate and partly as unchanged terbutaline, the ratio depending upon the route by which it is given. The terminal half-life after single and multiple dosing is reported to be between 16 and 20 hours. There is some placental transfer. Trace amounts are distributed into breast milk.
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