Betamethasone dipropionate, gentamicin sulfate, tolnaftate, clioquinol.
Each gram contains: Betamethasone (as dipropionate) 500 mcg, Gentamicin (as sulfate) 1 mg, Tolnaftate 10 mg, Clioquinol 10 mg.
Pharmacology: Pharmacodynamics/Pharmacokinetics: Betamethasone is a corticosteroid with anti-inflammatory activity used in the treatment of conditions for which corticosteroid therapy is indicated except adrenal-deficiency states for which hydrocortisone with supplementary fludrocortisone is preferred. Its virtual lack of mineralocorticoid properties makes betamethasone particularly suitable for treating conditions in which water retention would be a disadvantage.
Gentamicin is an aminoglycoside antibiotic and has a bactericidal action against many Gram-negative aerobes and against some strains of staphylococci. Aminoglycosides are taken up into sensitive bacterial cells by an active transport process which is inhibited in anaerobic, acidic, or hyperosmolar environments. Within the cell they bind to the 30S, and to some extent to the 50S, subunits of the bacterial ribosome, inhibiting protein synthesis and generating errors in the transcription of the genetic code. The manner in which cell death is brought about is imperfectly understood, and other mechanisms may contribute, including effects on membrane permeability.
Tolnaftate is an antifungal used in the treatment or prophylaxis of superficial dermatophyte infections and of pityriasis versicolor.
Clioquinol has antibacterial and antifungal activity used in the treatment of skin infections. It is applied with a corticosteroid in inflammatory skin conditions complicated by bacterial or fungal infections.
Used in the treatment of inflammatory manifestations of corticosteroid-responsive dermatoses when complicated by secondary infection caused by organisms sensitive to other dermatologic preparation or when the possibility of such infection is suspected.
Apply thin film to cover completely the affected area two or three times daily or as prescribed by the physician. Frequency of application should be determined according to severity of the condition. Duration of therapy varies depending upon the extent and location of disease and patient response.
Method of Administration: Topical.
This cream is contraindicated to those patients with a history of sensitivity reactions to any of its components.
Cautious use is recommended under these conditions, particularly in infants and children. Prolonged use of topical antibiotics occasionally may result in overgrowth of non-susceptible organisms. If this occurs or if irritation, sensitization or superinfection develops, treatment with Quadmix Cream should be discontinued and appropriate therapy instituted.
Pregnancy: Since safety of topical corticosteroid use in pregnant women has not been established, drugs of this class should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Drugs of this class should not be used extensively in large amounts or for prolonged periods of time in pregnant patients.
Lactation: Since it is not known whether topical administration of corticosteroids can result in sufficient systemic absorption to produce detectable quantities in breast milk, a decision should be made to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.
Any of the side effects that are reported following systemic use of corticosteroids, including adrenal suppression may also occur with topical corticosteroids, especially in infants and children. Cross allergenicity among aminoglycosides has been demonstrated. Systemic absorption of topically applied gentamicin may be increased if extensive body surface areas are treated, especially over prolonged time periods or in the presence of dermal disruption. In these cases, the undesirable effects which occur following systemic use of gentamicin may potentially occur.
Store at temperatures not exceeding 30°C.
D07CC01 - betamethasone and antibiotics ; Belongs to the class of potent (group III) corticosteroids, in combination with antibiotics. Used in the treatment of dermatological diseases.
Topical cream (tube) 5 g x 1's.