Rabeprazole: Rabeprazole is metabolized in the liver by cytochrome P450 (CYP450). Hence, coadministration with warfarin could lead to increase in prothrombin time although it is not significant.
Even metabolism of cyclosporine is inhibited by rabeprazole when concomitantly advocated. Since Rabeprazole Sodium + Itopride Hydrochloride inhibits gastric acid secretion, it could interfere with absorption of drugs wherein gastric pH is an important determinant of bioavailability like ketoconazole.
Itopride: No interactions with regard to serum binding have been detected for itopride with warfarin, diazepam, diclofenac, ticlopidine, nifedipine and vice-versa. Metabolic interactions are not to be expected because itopride is mainly metabolized by flavin monooxygenase and not by cytochrome P450. Anticholinergic agents may reduce the action of itopride. Antiulcer agents like cimetidine, ranitidine did not affect the prokinetic action of itopride.