Rabeprazole Sodium + Itopride Hydrochloride should be used during pregnancy only if the potential benefit justifies the probable risks involved. In view of likelihood of rabeprazole to be excreted in human milk, and because of potential for adverse reactions in nursing infants, a decision should be made whether to discontinue nursing or Rabeprazole Sodium + Itopride Hydrochloride taking into account the importance of therapy to the mother. Safety and efficacy of Rabeprazole Sodium + Itopride Hydrochloride ingredients in children have not been established.