Patients w/ ischemic heart disease & those at risk of heart disease, HTN, hyperlipidemia, diabetes, smoking; peripheral arterial disease. Risk of CV, GI, renal & hepatic effects; fluid retention & edema; anaphylactoid & serious skin reactions. Concomitant use w/ warfarin or similar agents; non-aspirin NSAID. May diminish utility of diagnostic signs eg, fever in detecting infections. Not a substitute for aspirin in the prophylactic treatment of CV disease. Pregnancy & lactation.