Rhea Cilostazol

Rhea Cilostazol

cilostazol

Manufacturer:

Korea Otsuka

Distributor:

Philusa

Marketer:

Philusa
Concise Prescribing Info
Contents
Cilostazol
Indications/Uses
Ischemic symptoms eg, ulceration, pain & coldness of extremities, in chronic arterial occlusion. Prevention of recurrence of cerebral infarction (excluding cardiogenic cerebral embolism).
Dosage/Direction for Use
PO Adult 100 mg bid, may be adjusted according to the age of patient & severity of symptoms.
Administration
Should be taken on an empty stomach: Take at least 30 min before or 2 hr after meals.
Contraindications
Hypersensitivity. Patients w/ hemorrhage (eg, hemophilia, increased capillary fragility, intracranial hemorrhage, hemorrhage in the digestive & urinary tract, hemoptysis & hemorrhage in the vitreous body); CHF. Pregnancy.
Special Precautions
Closely monitor patients for any anginal symptoms (eg, chest pain). Not to be administered to patients w/ cerebral infraction until condition is stabilized. Discontinue use or dosage reduction if excessive increase in pulse rate is observed in patients w/ coronary artery stenosis. Risk of menorrhagia in patients during menstruation. Patients w/ bleeding tendency or predisposition to bleeding, coronary artery stenosis, DM or abnormal glucose tolerance, severe HTN w/ consistently high BP eg, malignant HTN. Patients on anticoagulants (eg, warfarin), antiplatelets (eg, aspirin or ticlopidine), thrombolytics (eg, urokinase or alteplase), or prostaglandin E1 or its derivatives (eg, alprostadil). Monitor patients for development of new systolic murmur or cardiac symptoms after starting treatment. Severe hepatic & severe renal impairment. Lactation. Childn. Elderly.
Adverse Reactions
Rash; palpitation, tachycardia & hot flushes; headache/dull headache, dizziness, insomnia & numbness; abdominal pain, nausea, vomiting, anorexia, diarrhea, heartburn & abdominal distention; SC hemorrhage; increase in AST, ALT, alkaline phosphatase, lactate dehydrogenase; sweating, edema & chest pain.
Drug Interactions
May increase bleeding tendency w/ anticoagulants (eg, warfarin), antiplatelets (eg, aspirin & ticlopidine), thrombolytics (eg, urokinase & alteplase), prostaglandin E1 or its derivatives (eg, alprostadil). Increased blood conc w/ CYP3A4 inhibitors [macrolides (eg, erythromycin), HIV PIs (eg, ritonavir), azole antimycotics (eg, itraconazole & miconazole), cimetidine, diltiazem & grapefruit juice] & CYP2C19 inhibitors (eg, omeprazole).
MIMS Class
Anticoagulants, Antiplatelets & Fibrinolytics (Thrombolytics)
ATC Classification
B01AC23 - cilostazol ; Belongs to the class of platelet aggregation inhibitors excluding heparin. Used in the treatment of thrombosis.
Presentation/Packing
Form
Rhea Cilostazol tab 100 mg
Packing/Price
100's (P2,900/box)
Form
Rhea Cilostazol tab 50 mg
Packing/Price
100's (P1,650/box)
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