Endocrine Disorders: Primary or secondary adrenocortical insufficiency (hydrocortisone or cortisone is the first choice; synthetic analogs may be used in conjunction with mineralocorticoids, where applicable, in infancy, mineralocorticoid supplementation is of particular importance): Congenital adrenal hyperplasia; Non-suppurative thyroiditis; Hypercalcemia associated with cancer.
Non-Endocrine Disorders: Rheumatic Disorders: As adjunctive therapy for short-term administration (to tide the patient over an acute episode or exacerbation) in: Psoriatic arthritis; Acute gouty arthritis; Rheumatoid arthritis, including juvenile rheumatoid arthritis (selected cases may require low-dose maintenance therapy); Post-traumatic osteoarthritis; Ankylosing spondylitis; Synovitis of osteoarthritis; Acute and subacute bursitis; Epicondylitis; Acute nonspecific tenosynovitis.
Collagen Diseases: During an exacerbation or as maintenance therapy in selected cases of: Systemic lupus erythematosus; Polymyalgia rheumatica; Systemic dermatomyositis (polymyositis); Giant cell arteritis; Acute rheumatic carditis.
Dermatologic Diseases: Pemphigus; Bullous dermatitis herpetiformis; Severe erythema multiforme (Stevens-Johnson syndrome); Exfoliative dermatitis; Mycosis fungoides; Severe psoriasis; Severe seborrheic dermatitis.
Allergic States: Control of severe or incapacitating allergic conditions intractable to adequate trials of conventional treatment: Seasonal or perennial allergic rhinitis; Drug hypersensitivity reactions; Serum sickness; Contact dermatitis; Bronchial asthma; Atopic dermatitis.
Ophthalmic Diseases: Severe acute and chronic allergic and inflammatory processes involving the eye and its adenexa such as: Allergic corneal marginal ulcers; Allergic conjunctivitis; Herpes zoster ophthalmicus; Keratitis; Anterior segment inflammation; Chorioretinitis; Diffuse posterior uveitis and choroiditis; Optic neuritis; Sympathetic ophthalmia; Iritis and iridocyclitis.
Respiratory Disease: Symptomatic sarcoidosis; Fulminating or disseminated pulmonary tuberculosis when used concurrently with appropriate antituberculous chemotherapy; Loeffler's syndrome not manageable by other means; Aspiration pneumonitis; Berylliosis.
Hematologic Disorders: Idiopathic thrombocytopenic purpura in adults; Erythroblastopenia (RBC anemia); Secondary thrombocytopenia in adults; Congenital (erythroid) hypoplastic anemia; Acquired (autoimmune) hemolytic anemia.
Neoplastic Diseases: For palliative management of: Leukemias and lymphomas in adults; Acute leukemia of childhood.
Edematous States: To induce a diuresis or remission of proteinuria in the nephrotic syndrome, without uremia, or the idiopathic type or that due to lupus erythematosus.
Gastrointestinal Diseases: To tide the patient over a critical period of the disease in: Ulcerative colitis; Regional enteritis.
Nervous System: Acute exacerbations of multiple sclerosis; Management of edema associated with brain tumor.
Miscellaneous: Tuberculous meningitis with subarachnoid block or impending block when used concurrently with appropriate antituberculous chemotherapy; Trichinosis with neurologic or myocardial involvement.