Rhea Phenobarbital

Rhea Phenobarbital

phenobarbital

Manufacturer:

Philusa

Distributor:

Philusa
Full Prescribing Info
Contents
Phenobarbital.
Action
Anticonvulsant.
Indications/Uses
Antiepileptic agent to control tonic-clonic (grand mal) and partial (focal) seizures.
Dosage/Direction for Use
As prescribed by the physician.
Overdosage
Symptoms: The toxic effects of overdosage include prolonged coma, respiratory depression and cardiovascular depression with hypotension and shock leading to renal failure. Hypothermia is common, with associated pyrexia during recovery.
Treatment: Following the recent ingestion of an overdose of a barbiturate, the stomach may be emptied by gastric lavage and aspiration. The prime objectives of management are then intensive symptomatic and supportive therapy with particular attention being paid to the maintenance of the electrolyte balance.
Several methods aimed at the active removal of a barbiturate with a long elimination half-life, eg phenobarbital have been employed and include forced diuresis, hemodialysis, peritoneal dialysis and charcoal hemoperfusion, but with the possible exception of charcoal hemoperfusion the hazards of such procedures are generally considered to outweigh any purported benefits.
Warnings
May be habit forming.
Special Precautions
Phenobarbital and other barbiturates should be used with care in children and elderly patients and in patients with impaired hepatic, renal or respiratory function and are contraindicated when the impairment is severe.
Effects on the Ability to Drive or Operate Machinery: Phenobarbital and other barbiturates cause drowsiness and patients receiving them, if affected, should not take charge of vehicles or machinery where loss of attention could cause accidents.
Adverse Reactions
Include respiratory depression, sedation and occasional allergic reactions, particularly affecting the skin. Nystagmus and ataxia may occur with excessive doses, and irritability and hyperexcitability may occur particularly in children or the elderly. Folate deficiency has developed during chronic administration of phenobarbital and hypoprothrombinemia has occurred in infants of mothers who have received phenobarbital during pregnancy.
Drug Interactions
Phenobarbital and other barbiturates may reduce the activity of many drugs by increasing the rate of metabolism through induction of drug-metabolising enzymes in liver microsomes. Drugs which may be affected include carbamazepine, coumarin anticoagulants, cyclosporin, doxycycline, phenylbutazone, metronidazole, phenytoin, quinidine, theophylline, tricyclic antidepressants and corticosteroids and other steroid hormones including oral contraceptives. Phenobarbital may also reduce the activity of griseofulvin although the mechanism is not entirely clear.
Storage
Store at room temperature not exceeding 30°C.
MIMS Class
ATC Classification
N03AA02 - phenobarbital ; Belongs to the class of barbiturates and derivatives antiepileptics.
15 mg tab:Rx;30, 60 & 90 mg tab:EDD, Rx
Presentation/Packing
Tab 15 mg x 100's. 30 mg x 100's. 60 mg x 100's. 90 mg x 100's.
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