Rhea Sultamicillin Tosylate

Rhea Sultamicillin Tosylate





Concise Prescribing Info
Sultamicillin tosylate
Infections in upper resp (including sinusitis, otitis media & tonsillitis) & lower resp (including bacterial pneumonias & bronchitis) tract infections; UTI & pyelonephritis; skin & soft tissue, intra-abdominal & gonococcal infections.
Dosage/Direction for Use
Adult & elderly 375-750 mg bid for 5-14 days. Continued until 48 hr after pyrexia & other abnormal signs in adult & childn. Uncomplicated gonorrhea 2.25 g as single dose (six 375 mg or three 750 mg) w/ 1 g probenecid. Childn ≥30 kg Adult dose, ≤30 kg 25-50 mg/kg/day in 2 divided doses.
May be taken with or without food.
Hypersensitivity to sultamicillin & penicillins.
Special Precautions
Patients w/ history of penicillin hypersensitivity &/or hypersensitivity reactions to multiple allergens. Discontinue if serious & occasionally fatal hypersensitivity (anaphylactic) reactions; severe skin reactions eg, toxic epidermal necrolysis, Stevens-Johnson syndrome, dermatitis exfoliative & erythema multiforme; super-infection. C. difficile-associated diarrhea which may range from mild diarrhea to fatal colitis. Drug induced liver injury eg, cholestatic hepatitis & jaundice. Not to be used in infectious mononucleosis. Check periodically for organ system dysfunction (renal, hepatic & hematopoietic systems). Avoid in patients w/ galactose intolerance, Lapp-lactase deficiency or glucose-galactose malabsorption. Pregnancy & lactation. Neonates.
Adverse Reactions
Pseudomembranous colitis, candida infection; thrombocytopenia; anaphylactic shock & reaction, hypersensitivity; dizziness, somnolence, sedation, headache; dyspnea, enterocolitis, melena, diarrhea, vomiting, abdominal pain, dyspepsia, nausea, stomatitis, dysgeusia, tongue discoloration; jaundice, abnormal hepatic function; toxic epidermal necrolysis, Stevens-Johnson syndrome, erythema multiforme, angioedema, urticaria, dermatitis, rash, pruritus; arthralgia; fatigue, malaise; increased ALT/AST; agranulocytosis, hemolytic anemia, thrombocytopenic purpura, leukopenia, neutropenia, eosinophilia, anemia; anaphylactoid shock/reaction; convulsion; glossitis; hepatitis cholestatic, cholestasis, hyperbilirubinemia; dermatitis exfoliative, acute generalized exanthematous pustulosis; tubulointerstitial nephritis; abnormal platelet aggregation.
Drug Interactions
Increased incidence of rashes w/ allopurinol. May produce alterations in platelet aggregation & coagulation tests w/ anticoagulants. May interfere bactericidal effects of penicillins w/ bacteriostatic drugs (chloramphenicol, sulfonamides & tetracyclines). May reduce effectiveness of estrogen-containing OCs. Decreased clearance of methotrexate & corresponding increase in methotrexate toxicity. Decreased renal tubular secretion w/ probenecid resulting to increased & prolonged serum conc, prolonged elimination half-life & increased risk of toxicity. False +ve glycosuria in urinalysis using Benedict/Fehling reagent & Clinitest. Transient decrease in plasma conc of total conjugated estriol, estriol-glucuronide, conjugated estrone & estradiol in pregnant women.
MIMS Class
ATC Classification
J01CR04 - sultamicillin ; Belongs to the class of penicillin combinations, including beta-lactamase inhibitors. Used in the systemic treatment of infections.
Rhea Sultamicillin Tosylate tab 375 mg
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